OBJECTIVE Care of critically ill children includes sedation but current therapies are suboptimal. To describe dexmedetomidine use in children supported on mechanical ventilation for acute respiratory failure. DESIGN Secondary analysis of data from the Randomized Evaluation of Sedation Titration for Respiratory Failure clinical trial. SETTING Thirty-one PICUs. PATIENTS Data from 2,449 chil...

OBJECTIVE This large-scale retrospective review evaluates the sedation profile of dexmedetomidine. AIM To determine the hemodynamic responses, efficacy and adverse events associated with the use of high dose dexmedetomidine as the sole sedative for magnetic resonance imaging (MRI) studies. BACKGROUND Dexmedetomidine has been used at our institution since 2005 to provide sedation for pediatr...

BACKGROUND Dexmedetomidine is a highly selective α(2)-adrenoceptor agonist that is widely used for sedation and analgesia during the perioperative period. Intravenous administration of dexmedetomidine induces transient hypertension due to vasoconstriction via the activation of the α(2)-adrenoceptor on vascular smooth muscle. The goal of this in vitro study is to investigate the calcium-dependen...

AIMS To investigate the effects and underlying mechanism of dexmedetomidine on the cultured human dendritic cells (DCs). METHODS Human DCs and cytotoxic T lymphocytes (CTLs) were obtained from human cord blood mononuclear cells by density gradient centrifugation. Cultured DCs were divided into three groups: dexmedetomidine group, dexmedetomidine plus yohimbine (dexmedetomidine inhibitor) grou...

proved for use as a sedative and analgesic in intensive care unit (ICU). Dexmedetomidine is seven to eight times more specific to the alpha-2 receptor than the partial agonist clonidine. In addition to its sedative properties, dexmedetomidine has opioidsparing, anxiolytic, sympatholytic, and respiratory-preserving properties and provides superior hemodynamic stability compared with many sedativ...

results there was no statistically significant difference between the mmse scores of the two groups before surgery (p = 0.6), but the mmse test conducted at the pacu revealed significantly better cognitive outcomes in the d group than in the r group in patients younger and older than 65 years (p = 0.03 and p = 0.0001, respectively). conclusions this study revealed that dexmedetomidine may be a ...

BACKGROUND Patients undergoing alcohol withdrawal in the intensive care unit (ICU) often require escalating doses of benzodiazepines and not uncommonly require intubation and mechanical ventilation for airway protection. This may lead to complications and prolonged ICU stays. Experimental studies and single case reports suggest the α2-agonist dexmedetomidine is effective in managing the autonom...

normal 0 false false false en-us x-none ar-sa background: t he aim of the study is to compare the effects of remifentanil/dexmedetomidine and remifentanil/midazolam combinations in monitored anesthesia care (mac) during cystoscopies. materials and methods: f orty patients who received remifentanil infusion of 0.05 m g kg -1 min -1 for cytoscopy procedure were randomized into two groups: e ither...

BACKGROUND Dexmedetomidine (Precedex; Abbott Laboratories, Abbott Park, IL) is a selective alpha2-adrenergic agonist that also has affinity for imidazoline receptors. In clinical studies, dexmedetomidine has sedative effects and impairs memory, but the action of dexmedetomidine on synaptic plasticity in the brain has yet to be established. In the present study, the authors investigated the effe...

BACKGROUND AND OBJECTIVES The administration of powerful and short duration anesthetic agents is essential for patients undergoing bariatric surgical procedure. The dexmedetomidine, an alpha 2-adrenergic agonist, has appeared as an adjuvant option of the venous anesthesia technique. This study aimed at assessing the efficacy of dexmedetomidine associated with the venous anesthesia in morbid obe...