OBJECTIVES This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. METHODS To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant st...

While the pathogenesis of acetic acid (AA)-induced colitis is unclear, reactive oxygen species are considered to have a significant effect. The aim of the present study was to elucidate the therapeutic potential of dexpanthenol (Dxp) on the amelioration of colitis in rats. Group I (n=8; control group) was intrarectally administered 1 ml saline solution (0.9%); group II [n=8; AA] was administere...

We present the case of a 59-year-old female patient with severe Coronavirus Acute Respiratory Distress Syndrome (CARDS) admitted to Intensive Care Unit (ICU). Prior SARS-CoV-2 infection she had no other medical problems besides chronic arterial hypertension. Endotracheal intubation became necessary. Between five episodes therapeutic prone positioning during mechanical ventilation, swelling lowe...

An 11-year-old girl presented with a history of two episodes of facial eczema, which developed 1 day after the application of make-up that was removed with ‘hypoallergenic’ facial wipes. She was patch tested with the British Society for Cutaneous Allergy baseline series, a facial series (Chemotechnique Diagnostics, Vellinge, Sweden), and the facial wipes (the only ‘own’ product made available f...

Aflatoxin effects on duckling growth and rates of changes in liver, bile, and plasma components during 10&y bioassay periods were deternlined with the WIIO/FAO/ ITNICEF-defined 60% peanntmeal diet. Aflatosin at 1.578 pg/g feed (0.948 1.19 B, and 0.630 ,LL~ G, ( depreised growth 78X, reduced feed conversion efficiency 60X, increased liver size 42%, and rednced bile rihoHavin 94%:. The toxin indu...

OBJECTIVE To analyze the effect of ultrasound (US), dexpanthenol (d-P) and a combination of these treatments (US+d-P) on collagen fiber organization in tegumentary lesions in rats by birefringence analysis. METHODS Wistar rats (50) were anesthetized (Thionembutal - Sodic = 50 mg/Kg), 1 cm² of dorsal region skin was removed, and the animals were divided into five groups: control (C), gel (G), ...

Every year there is an increase in the number of cases hypersensitivity to bites from various insects. A local allergic reaction occurs within a few minutes and accompanied by acute pain at site bite, severe itching, hyperemia, appearance papules, tissue edema, sometimes small-point rash around. Considering small drugs for therapy manifestations unidirectional nature their action, it urgent dev...