Mathematical models of cell electrical activity typically consist of a current balance equation, channel activation (or inactivation) variables and concentrations of regulatory agents. These models can be thought of as nonlinear filters whose input is some applied current I (possibly zero) and output is a membrane potential V. A natural question to ask is if the applied current I can be deduced...

Activated phospholipase C (PLC*) generates 1,4,5-triphosphate (IP3) and diacylglycerol (DAG) from phosphatidyl inositol (PIP2). The DAG remains in the plasma membrane and co-activates conventional protein kinase C (PKC) with Ca2+. We have developed a mathematical model for the activation of the Ca2+-dependent PKC and its negative feedback on phospholipase C (PLC) and coupled it to the De Young-...

Authors Note Michael P. Wilmot and Colin G. DeYoung, Department of Psychology, University of Minnesota; David Stillwell and Michal Kosinski, The Psychometrics Centre, University of Cambridge, Cambridge, United Kingdom. Portions of this article were presented at the 28 th annual conference of the Society for Industrial and Organizational Psychology, April 2013, Houston, Texas. We thank Mark Snyd...

Many models of bursting electrical activity (BEA) in pancreatic β-cells have been proposed. BEA is characterized by a periodic oscillation of the membrane potential consisting of a silent phase during which the membrane potential is varying slowly and an active phase during which the membrane potential is undergoing rapid oscillations. An important experimental observation of BEA is a correlati...

Este artigo trata, sob uma perspectiva discursivo-funcional, do tradicionalmente chamado, em gramáticas de língua portuguesa, aposto oração, com o objetivo analisar suas funções textual-discursivas. A base teórica é a Gramática Discursivo-Funcional (GDF), Hengeveld e Mackenzie (2008), estudos descritivos sobre aposição, tais como Quirk et al. (1985), Meyer (1992), Hannay Keizer (2005), (2015), ...