BACKGROUND The insulin receptor substrate 1 (IRS1), phosphoinositide 3-kinase (Pi3k), protein kinase B (Akt1), Forkhead Box O3a (FOXO3a) pathway is directly involved in aging and ovarian activation of follicle growth. Therefore, the aim of this work was to measure the expression of genes related to the ovarian pathway for activation of primordial follicles and FOXO3a protein phosphorylation bet...

CONTEXT Limited ankle DF (DF) range of motion (ROM) resulting from restricted gastrocnemius and soleus mobility is associated with a variety of lower extremity pathologies. Several techniques are used clinically to measure ankle DF. OBJECTIVES To evaluate the reliability and minimal detectable change of DF ROM measurement, determine whether there is a difference in measured DF between techniq...

We analyzed levels of PCDD/DF in leachate liquid and solid from five Korean municipal solid waste landfills to investigate the relationship between PCDD/DF and dissolved organic carbon and suspended solids in raw leachate. The concentrations of PCDD/DF ranged from 173.2 to 1329.4 pg/l and 4.1 to 46.22 pg-TEQ/l. The range of PCDD/DF was 123.2-1161.3 pg/l in leachate solid and 50.0-383.3 pg/l in ...

Defibrotide (DF) has received European Medicines Agency authorization to treat sinusoidal obstruction syndrome, an early complication after hematopoietic cell transplantation. DF has a recognized role as an endothelial protective agent, although its precise mechanism of action remains to be elucidated. The aim of the present study was to investigate the interaction of DF with endothelial cells ...

The role of the duty factor (DF) in ultrasound-mediated cardiac stimulation is studied. Five 3-month-old female rats were exposed transthoracically to 3.5-MHz ultrasonic pulses of 2.0-MPa peak rarefactional pressure amplitude, variable DF, and variable pulse repetition frequency. A change in the heart rate was not observed following the 0.25%-DF sequence. A decrease of ∼4% in the heart rate was...

We examined the spatial distribution pattern and meteorological drivers of dengue fever (DF) in Guangdong Province, China. Annual incidence of DF was calculated for each county between 2005 and 2011 and the geographical distribution pattern of DF was examined using Moran's I statistic and excess risk maps. A time-stratified case-crossover study was used to investigate the short-term relationshi...

Although the metabolism and disposition of diclofenac (DF) has been studied extensively, information regarding the plasma levels of its acyl-β-d-glucuronide (DF-AG), a major metabolite, in human subjects is limited. Therefore, DF-AG concentrations were determined in plasma (acidified blood derived) of six healthy volunteers following a single oral DF dose (50 mg). Levels of DF-AG in plasma were...

N 27 27 – Age [years; months] (age range) 10;5±2;7 (6;6–16;4) 11;0±1;11 (8;5–17;0) T=0.81; df=52; P=.42 Sex (f/m) 8/19 7/20 χ=0.09; df=1; P=.76 IQ 80±17 107±12 T=6.55; df=52; Pb .01 CBCL (total t-score) 64.08±9.05 (n=25) 48.67±5.38 T=−7.54; df=50; Pb .01 General ADHD symptoms 1.00±0.51 (n=24) 0.30±0.23 (n=26) T=−6.37; df=48; Pb .01 Depressive symptoms 48.96±9.95 (n=26) 42.89±8.00 T=−2.45; df=51...

BACKGROUND Dengue fever (DF) outbreaks often arise from imported DF cases in Cairns, Australia. Few studies have incorporated imported DF cases in the estimation of the relationship between weather variability and incidence of autochthonous DF. The study aimed to examine the impact of weather variability on autochthonous DF infection after accounting for imported DF cases and then to explore th...

The increase in use and misuse of psychoactive substances is a global challenge of grave public health concern. This study aims to ascertain the patterns and socio-demographic correlates of psychoactive substances among undergraduates in a Nigerian University. Two hundred and ninety three subjects participated in the study. Questionnaires on risk factors and variation of psychoactive substances...