Patients with diabetes have been reported to be at an increased risk for cancers of the pancreas, liver, and colon; however, recent studies have suggested that men with diabetes are at a decreased risk for prostate cancer. Previous studies have found that obese men have lower serum prostate-specific antigen (PSA) concentrations than do non-obese men. Further understanding of how obesity and dia...

The plasma cell differentiation antigen (PC-1) is an inhibitor of insulin receptor tyrosine kinase activity and is a major factor of insulin resistance in patients with type 2 diabetes mellitus. We have studied lymphocyte PC-1 (ecto-alkaline phosphodiesterase I, APD I) in obese type 2 diabetics, as well as plasma level and urinary excretion of PC-1. Fifteen patients (8 female, 7 male) with a BM...

Please cite this paper as: Fereidoun Azizi. Obesity Dilemma: Are There Enough Bariatric Surgeons? Int J Endocrinol Metab. 2012;10(4):580-1. DOI: 10.5812/ ijem.7929 Implication for health policy/practice/research/medical education: Baratric surgery has shown to be the most effective treatment for morbid obesity and obese diabetics. However the number of surgeons for all the operations indicated ...

BACKGROUND The rising incidence of non alcoholic fatty liver disease (NAFLD) mirrors the epidemics of obesity and metabolic syndrome. Primary care practitioners (PCPs) are central to management of patients with NAFLD, but data on knowledge and attitudes of PCPs towards NAFLD are lacking. MATERIAL AND METHODS We conducted a statewide, stratified survey of 250 PCPs to examine knowledge, practic...

Background. We investigated the effect of laparoscopic sleeve gastrectomy (LSG) on morbidly obese diabetics and examined the short-term impact of LSG on diabetic medication cost. Methods. A prospective database of consecutive bariatric patients was reviewed. Morbidly obese patients with type 2 diabetes who underwent LSG were included in the study. Age, gender, body mass index (BMI), diabetic me...

The obese first degree relatives of type 2 diabetics are more prone to develop diabetes mellitus in later life. Having one parent with carries 1.6 fold and both the parents (T2DM) has 3.2 higher risk developing T2DM. Lipid accumulation product (LAP) is a simple reliable index central lipid accumulation. It combines waist circumference triacyglycerols. Studies have revealed that LAP better indic...

It has long been known that the brain, especially the hypothalamus, can modulate both insulin secretion and hepatic glucose fluxes, via the modulation of the sympathetic system (promoting glycogen breakdown) and the parasympathetic system (stimulating glycogen deposition). Central insulin signalling or hypothalamic long-chain fatty acid oxidation can also control insulin's suppression of endoge...

We examined whether, in human obesity and type 2 diabetes, long chain fatty acid (LCFA) transport into skeletal muscle is upregulated and contributes to an excess intramuscular triacylglycerol accumulation. In giant sarcolemmal vesicles prepared from human skeletal muscle, LCFA transport rates were upregulated approximately 4-fold and were associated with an increased intramuscular triacylglyce...

SUMMARY Due to the importance of coronary heart diseases in today's world and in view of the fact that hyperlipidemia, hyperglycemia and obesity are regarded as the main risk factors in these diseases and also considering the paucity of epidemiologic surveys in our society, this study was carried out in Islamshahr 30 Km to the southwest of Tehran. Out of 244000 population of the area, 2033 per...