Disseminated intravascular coagulopathy (DIC) (see Figure 1) is a complex, life-threatening condition that causes a hypercoagulative state, resulting in inappropriate activation of the coagulation cascade (see Figure 2). Activation of the coagulation cascade is triggered by the release of tissue factor (TF), a transmembrane glycoprotein (McCance & Huether, 2006). On release of TF, the coagulati...

Introduction. Acute lymphoblastic leukemia (ALL) is the most common type of leukemia, a deadly white blood cell disease that impacts human bone marrow. ALL detection in its early stages has always been riddled with complexity and difficulty. Peripheral smear (PBS) examination, method applied at outset diagnosis, time-consuming tedious process largely depends on specialist’s experience. Material...

Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of Philadelphia chromosome and BCR-ABL fusion oncogene. CML one illnesses that may be treated using Tyrosine Kinase Inhibitors (TKIs), type targeted therapy. Since TKIs are standard therapy, long-term survival has improved compared to chemotherapy interferon-alpha. For first-line treatment for CML, the...

acute leukemia which is the most common cancer in children is a heterogeneous group of clonal malignancies. the conversion of the leukemic cell lineage during the course of the disease or later is termed lineage switch. it has been rarely reported in the literature. in leukemia lineage switch, conversions from lymphoblastic leukemia to myeloid leukemia or vice versa are reported. herein, we rep...

Objectives Chronic recurrent multifocal osteomyelitis (CRMO), the most severe form of chronic nonbacterial osteomyelitis (CNO), is an autoinflammatory bone disorder. In the absence of diagnostic criteria or biomarkers, CNO/CRMO remains a diagnosis of exclusion. The aim of this study was to identify biomarkers for diagnosing multifocal disease (CRMO). Study design Sera from 71 pediatric CRMO p...

Flow cytometry is the preferred method of diagnosing and immunophenotyping acute lymphoblastic leukemia (ALL). However, there are situations in which immunohistochemical staining (IH) of bone marrow trephine biopsy specimens can be used to provide immunophenotypic information. To evaluate the use of IH and to confirm its value in diagnosing and typing of ALL, we studied 50 cases of denovo ALL t...

Background: Environment of Basrah is seriously contaminated with chemical leukomogens as a result of recent military conflicts. Many studies in the past few years have reported an increase in the incidence of leukemia in Basrah. This study was designed to study the risk and pattern of childhood leukemia in Basrah, Iraq, from 2003 to 2007.Materials and Methods: This hospital-based cancer registr...

Acute leukemia which is the most common cancer in children is a heterogeneous group of clonal malignancies. The conversion of the leukemic cell lineage during the course of the disease or later is termed lineage switch. It has been rarely reported in the literature. In leukemia lineage switch, conversions from lymphoblastic leukemia to myeloid leukemia or vice versa are reported. Herein, we rep...

background: about 8 percent of all cancers in human population are related to leukemia and it is one of the most common malignancies in children. the aim of this study was to compare the prevalence of age, gender and blood group types with the frequency of leukemia among the children with leukemia in qazvin province during the 2006 to 2016. m aterials and methods: this was a cross-sectional ana...