Abstract Background and Aims Anaemia is a common manifestation in patients with chronic kidney disease (CKD).1,2 Daprodustat, hypoxia-inducible factor prolyl hydroxylase inhibitor, offers an alternative to conventional treatment recombinant human erythropoietins (rhEPOs). This study reports the development of cost-effectiveness analysis support reimbursement discussions for daprodustat Canada. ...

The correction of anemia in dialysis patients with erythropoietin (EPO) can be frustrated by insufficient iron. To address this effect, we preloaded candidate EPO patients with intravenous iron in the early 1990s. Preloading with 900-1,525 mg of iron yielded the following results: 70% of patients had increasing hematocrits (HCTs) without EPO, and 40% of patients had HCTs greater than 30%. Appar...

Comment The histological appearance of the amyloid (apple green birefringence under polarised light after staining with Congo red and resistance to pretreatment with potassium permanganate) in each case was consistent with dialysis related amyloidosis and not deposition of AA amyloid. In both patients immunohistology showed strong positivity of the amyloid deposits for P2 microglobulin and weak...

BACKGROUND AND OBJECTIVES Adhesion and colonization are prerequisites for the establishment of bacterial pathogenesis. The biofilm development of Pseudomonas aeruginosa was assessed on adhesive surfaces like dialysis membrane, stainless steel, glass and polystyrene. MATERIALS AND METHODS Microtiter plate biofilm assay was performed to assess the effect of nutrient medium and growth parameters...

background: accumulation or deficiency of trace elements can occur in hemodialysis patients and it increases risk of cardiovascular or other organs disorders. special ions levels such as sodium and bicarbonate in dialysis fluid are accurately regulated but the remaining elements are not regularly measured. aluminum and lead belong to the biologic performance free heavy metals .they also has a t...

The pharmacokinetics of recombinant human erythropoietin (rHuEpo) administered intravenously has been investigated in a group of five patients with chronic renal failure who were dialysis-dependent. The half-life of circulating erythropoietin decreased from 7.9±OA hr (mean ±SO) at the beginning of treatment to 6.2±O.6 hr after 6 weeks and 5A±O.9 hr after 4 months of treatment. In spite of t...

38. Canaud B, Mingardi G, Braun J et al. STRIATA Study Investigators. Intravenous C.E.R.A. maintains stable haemoglobin levels in patients on dialysis previously treated with darbepoetin alfa: results from STRIATA, a randomized phase III study. Nephrol Dial Transplant 2008; 23: 3654–3661 39. Levin NW, Fishbane S, Cañedo FV et al. MAXIMA Study Investigators. Intravenous methoxy polyethylene glyc...

Background: Accumulation or deficiency of trace elements can occur in hemodialysis patients and it increases risk of cardiovascular or other organs disorders. Special ions levels such as sodium and bicarbonate in dialysis fluid are accurately regulated but the remaining elements are not regularly measured. Aluminum and lead belong to the biologic performance free heavy metals .They also has a t...