in order to identify left ventricular diastolic function in patients with betathalassemia major and normal systolic function by noninvasive m-mode and doppler echocardiography, an analytic study was designed in a university hospital in sari. we have studied 44 patients (23 men and 21 women), mean age 15.48±2.16 (range 12 to 20) and 43 age and sex matched control subjects. peak flow velocity in ...

BACKGROUND Intracoronary physiology techniques have been validated extensively for the assessment of epicardial stenoses but not for the lone study of coronary microcirculation. We performed a comparison between 4 intracoronary physiological indices with the actual structural microcirculatory changes documented in transplanted hearts. METHODS AND RESULTS In 17 cardiac allograft patients witho...

Different patterns of left-ventricular (LV) diastolic dysfunction were reported in patients with pulmonary hypertension (PHT). There are no data regarding the relationship between the severity of PHT and LV diastolic dysfunction. In order to determine the severity of PHT at which LV diastolic dysfunction occurs and to identify its pattern, we studied by Doppler echocardiography 120 patients wit...

BACKGROUND The incidence of heart failure in diabetic subjects is high even in the absence of hypertension and coronary artery disease. AIMS The purpose of this study was to study the incidence of diastolic dysfunction in diabetic subjects and its relation to age, duration of diabetes mellitus (DM), Glycosylated hemoglobin (HbA1c) levels, obesity indices and diabetic microangiopathies. SETT...

Objective: To determine diagnostic utility of Doppler measurements in fetal descending aorta and umbilical arteries in predicting intrauterine growth retarded (IUGR) fetuses at risk in pregnancies complicated by pre-eclampsia and/or HELLP syndrome. Methods: Doppler measurements were taken in fetal descending aorta and umbilical arteries of 53 patients with pre-eclampsia, 10 of whom had HELLP sy...

BACKGROUND Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. METHODS We conducted a cross-sectional stu...

The aim of our study was to evaluate diastolic function of the left ventricle assessed by Doppler echocardiography in normal Doberman pinschers (DPs; n=39) and to study the effects of gender, age, body weight and heart rate on diastolic values. Diastolic echocardiographic values obtained in DPs were compared to the diastolic values in a group of Retrievers (n=20). The following correlations wer...

The conductance catheter is widely used for the continuous measurement of the left ventricular (LV) pressure-volume loops. Cyclical change of the right ventricular (RV) volume may alter the parallel conductance volume, thereby affecting the LV mechanical parameters. Using 8 open-chest adult mongrel dogs, multiple LV pressure-volume loops were obtained by 2 methods: first with a vena cava occlus...

Background: Transmitral Doppler flow indices are used to evaluate diastolic function. Recently, velocities measured by Doppler tissue imaging have been used as an index of left ventricular relaxation. Objective: To determine whether Doppler tissue velocities are influenced by alterations in preload. Methods: Left ventricular preload was altered in 17 patients (all men, mean (SD) age, 49 (8) yea...

Assessment of diastolic function has emerged as another important contribution of echocardiography to the clinical care of patients. Diastolic dysfunction as diagnosed by echocardiography carries a negative prognostic value,1–3 and diastolic assessment is now a routine part of any complete echocardiographic report.4 Bhella et al,5 in this issue of Circulation: Cardiovascular Imaging, investigat...