DIFFUSE TRAUMATIC AXONAL INJURY WITHIN THE VISUAL SYSTEM: IMPLICATIONS FOR VISUAL PATHWAY REORGANIZATION By Jiaqiong Wang, Ph.D. Candidate A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University Virginia Commonwealth University, 2012 Major Director: John T. Povlishock, Ph.D. Professor and Chairman Department ...

PURPOSE To assess the prevalence of MR evidence for diffuse axonal injury at 1.5 T in patients with normal head CT findings after mild head injury. METHODS Twenty consecutive patients with mild head injury (Glasgow Coma Scale, 13 to 15; no subsequent deterioration, loss of consciousness < 20 minutes) and normal head CT findings were examined with MR at 1.5 T. Pulse sequences included a conven...

This study characterized brain injuries with a focus on diffuse axonal injuries using the Crash Injury Research Engineering Network (CIREN) database, developed by the National Highway Safety Administration (NHTSA). Tier one and tier two medicaland crash-related data from 1997 to 2006 were used in the retrospective analysis. Diffuse axonal injuries injuries were assessed using the 1990 version o...

We investigated the therapeutic effect of vitamin D3 in a rat diffuse axonal injury model. A total of 60 male Sprague-Dawley rats weighing 175-200 g were anaesthetized and subjected to head trauma using Marmarou's impact-acceleration model. The rats were then separated into two groups; one group was treated with vitamin D3 and the other with saline for up to 4 days after the head trauma. Rats f...

One of the most critical neuropathological features of traumatic brain injury (TBI) is axotomy [1-5]. Even in mild (m) TBI, diffuse axotomy is easily and consistently observed as axons that end in swellings and dislocation from the distal part of the axon [6-8]. Integrity of axons can be measured in the clinical population with diffusion tensor imaging (DTI) [9-12]. Patient outcome has been cor...