نتایج جستجو برای: diffuse cutaneous scleroderma
تعداد نتایج: 124685 فیلتر نتایج به سال:
INTRODUCTION CREST (calcinosis, Raynaud phenomenon, oesophageal dysmotility, sclerodactyly, and telangiectasia) syndrome comprising calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia and primary sclerosing cholangitis are both chronic fibrotic diseases but the association between them is extremely rare. While primary sclerosing cholangitis has been as...
BACKGROUND In recent years we have observed with increasing frequency granulomatous papular lesions involving the knees, for which we proposed the term papular sarcoidosis of knees. OBJECTIVES To evaluate the clinicopathological features of papular sarcoidosis of the knees. METHODS Patients with papular lesions of the knees and histopathologically sarcoid granulomas were included in the stu...
Diffuse scleroderma (progressive systemic sclerosis) is a rheumatic disease characterized by inflammation, vascular sclerosis and fibrosis of the skin and viscera. The aetiology is uncertain and there is no effective form of therapy. The prognosis is poor and related to the extent of visceral, rather than cutaneous, involvement (Siegel, 1977). This disorder occasionally occurs in women of child...
BACKGROUND Studies on gastrointestinal symptoms, dysfunctions, and neurological disorders in systemic scleroderma are lacking so far. METHODS Thirty-eight scleroderma patients (34 limited, 4 diffuse), 60 healthy controls and 68 dyspeptic controls were scored for upper and lower gastrointestinal symptoms (dyspepsia, bowel habits), gastric and gallbladder emptying to liquid meal (functional ult...
The term "scleroderma" traditionally has been uti l ized to describe the cutaneous changes of a heterogeneous group of disorders involving hardening, tightening, and decreased elasticity of the skin.' Two extreme forms have been identified-localized and diffuse. The localized form, specifically morphea, i s characterized by well-circumscribed, sclerotic plaques with an ivory-colored center and ...
Because the current assessment of scleroderma skin through clinical skin scoring is subjective and imprecise, we investigated fully quantitative, physical measures of cutaneous involvement in the disease. First, we developed image analysis software for calculating the dermal density of colla-gen from 58 scleroderma and 327 control biopsies scanned onto our computer. Second, using a durometer ga...
OBJECTIVES The course of systemic sclerosis (SSc) can differ in female and male patients. According to the literature the incidence rates of diffuse cutaneous SSc, scleroderma renal crisis and digital ulceration are higher in male patients. The aim of the study was to compare selected clinical and serological parameters in male and female patients with SSc. MATERIAL AND METHODS The study enco...
OBJECTIVES Pulmonary fibrosis is a leading cause of death in systemic sclerosis (SSc). This report examines the differences at baseline and over 12 months between patients with limited versus diffuse cutaneous SSc who participated in the Scleroderma Lung Study. METHODS SSc patients (64 limited; 94 diffuse) exhibiting dyspnoea on exertion, restrictive pulmonary function and evidence of alveoli...
OBJECTIVE To assess the frequency and clinical correlates of the systemic sclerosis-related autoantibodies to RNA polymerases in Italian patients. METHODS Sera from 115 patients with systemic sclerosis (SSc) and 10 patients with systemic sclerosis-overlap syndromes recruited from a single center in northern Italy were investigated for antibodies to RNA polymerase I, II, and III by means of im...
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