BACKGROUND Hyperpigmentation disorders are common among those seeking care from dermatologists and primary care physicians. The cosmeceutical and natural product industries are rapidly growing and many botanical agents are purported to improve hyperpigmentation disorders. OBJECTIVE We sought to review clinical evidence for the use of botanical agents in the treatment of hyperpigmentation. M...

M inocycline hydrochloride is an important and effective treatment for acne vulgaris. While relatively few adverse effects have been documented, minocycline has been associated with cutaneous and mucosal hyperpigmentation in addition to hyperpigmentation of the teeth, sclera, bone, heart, and thyroid. We report a case of a woman who, while taking minocycline, developed discrete hyperpigmentatio...

BACKGROUND Diltiazem hydrochloride is a widely used calcium channel blocking agent. While a few cases of diltiazem-associated photosensitivity have been reported, no cases of photodistributed hyperpigmentation are known. OBSERVATION Four cases of photodistributed hyperpigmentation associated with the long-acting formulation of diltiazem hydrochloride (Cardizem CD) are presented. All patients ...

Cutaneous hyperpigmentation is a well-known side effect of tetracyclines, but doxycycline-induced cutaneous hyperpigmentation has only been described in one patient with a therapeutic dosage of doxycycline, and in one patient using suprapharmacological doses. We describe four patients with cutaneous hyperpigmentation in previously unaffected skin, and speculate that this was due to treatment wi...

background although, melasma is most prevalent among asian young women, and also darkly pigmented individuals are particularly prone to developing post inflammatory hyperpigmentation, to the best of our knowledge, there are rare or no studies about the association of melasma and post inflammatory hyperpigmentation. results we found out that 24.1% of patients without melasma had post-acne pigmen...

Background and objective: Peel oil and juice of citrus fruits have furocoumarin (Psoralen) that can induce phytophotodermatitis. If the reaction is mild, then only hyperpigmentation (Without itching, burning, erythema, vesicle and bullae, formation) may occur. The objective of this study was to describe the patients with hyperpigmentation of back of the hands. Materials and Methods: Thirty-two ...

Gingival hyperpigmentation is seen as a genetic trait in some populations irrespective of age and gender, hence it is termed physiologic or racial gingival pigmentation. Melanin, a brown pigment, is the most common natural pigment contributing to endogenous pigmentation of gingiva and the gingiva is also the most predominant site of pigmentation on the mucosa. Melanin pigmentation is the result...

5-FU: 5-fluorouracil FOLFIRI: 5-fluorouracil, irinotecan, and folinic acid TEC: toxic erythema of chemotherapy INTRODUCTION Here we describe a case of systemic FOLFIRIassociated balanitis successfully treated by topical steroids, without discontinuation of chemotherapy treatment. FOLFIRI consists of the pyrimidine analog antimetabolite, 5-fluorouracil (5-FU), the topoisomerase inhibitor, irinot...

Gingival hyperpigmentation is mostly caused by the physiologic deposition of melanin by melanocytes. Melanin pigmentation of the gingiva is completely benign and does not present a medical problem. In "Gummy Smile" Patients, melanin gingival hyperpigmentation causes an esthetic problem and physiologic disturbances. Many methods are now available for depigmentation of the gingival. This paper re...