Introduction: Diffusion weighted imaging is a powerful tool for the diagnosis of prostate cancer. In radiotherapy, delineation of the tumor for dose escalation is an important issue. Therefore, clear tumor boundaries have to be distinguished. In tumors, the diffusion direction of water is thought to be isotropic. The fractional anisotropy in the peripheral zone and central zone is reported to b...

OBJECTIVE The purpose of our study was to investigate whether fast and slow components of the apparent diffusion coefficient (ADC) from diffusion-weighted MR images could predict prostate cancer progression in patients managed by active surveillance. SUBJECTS AND METHODS Eighty-one patients managed by active surveillance underwent diffusion-weighted MRI in addition to T2-weighted MRI using an...

BACKGROUND Despite the established role of late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) in characterizing chronic myocardial infarction (MI), a significant portion of chronic MI patients are contraindicative for the use of contrast agents. One promising alternative contrast free technique is diffusion weighted CMR (dwCMR), which has been shown ex vivo to be sensitiv...

BACKGROUND AND PURPOSE The clinical usefulness and the time course of diffusion-weighted imaging and apparent diffusion coefficient (ADC) in acute and subacute cerebral infarction have not yet been established, although it is known that contrast-enhanced T1-weighted spin-echo imaging can detect a subacute infarct. Our aim was to study which imaging technique is useful in detecting recent infarc...

BACKGROUND Mass-forming focal pancreatitis (FP) may mimic pancreatic cancer (PC) on magnetic resonance (MR) imaging, and the preoperative differential diagnosis is often difficult. Recently, the usefulness of diffusion-weighted imaging (DWI) in the diagnosis of pancreatic cancer has been reported in several studies. PURPOSE To investigate if apparent diffusion coefficient (ADC) measurements b...

Diffusion weighted MRI has become ubiquitous in many areas of medicine, including cancer diagnosis and treatment response monitoring. Reproducibility of diffusion metrics is essential for their acceptance as quantitative biomarkers in these areas. We examined the variability in the apparent diffusion coefficient (ADC) obtained from both postprocessing software implementations utilized by the NC...

BACKGROUND AND PURPOSE In acute ischemic stroke, the amount of neuronal damage in hyperintense areas on MR diffusion imaging (DWI) is unclear. We used spectroscopic imaging to measure N-acetyl aspartate (NAA, a marker of normal neurons) and lactate (a marker of ischemia) to compare with diffusion and perfusion values in the diffusion lesion in acute ischemic stroke. METHODS We recruited patie...

OBJECTIVE To investigate the biexponential apparent diffusion parameters of diverse prostate tissues and compare them with monoexponential apparent diffusion coefficient (ADC) value in the efficacy to discriminate prostate cancer from benign lesions. MATERIALS AND METHODS Eleven healthy volunteers and 61 patients underwent a conventional (b-factors 0, 1000 s/mm(2)) and a 10 b-factor (0 to 300...

BACKGROUND AND PURPOSE The increasing interest in diffusion-weighted MRI (MRI) for diagnosis and monitoring of acute stroke in humans calls for a sound understanding of the underlying mechanisms of this image contrast in acute cerebral ischemia. The present study aimed to show that a rapid decrease in brain-water apparent diffusion coefficient (ADC) occurs coincident with anoxic depolarization ...

Purpose: The purpose of this study is to compare the diagnostic accuracy of prostate apparent diffusion coefficient (ADC) versus normalized prostate ADC using the normal peripheral zone as the reference site for the differentiation of prostate cancer and prostatitis in the peripheral zone. Methods: Fifty-two patients, 32 with prostate cancer and 19 with prostatitis, were assessed with single-sh...