The tris(2-pyridyl)phosphine oxide (Py3PO) complex [Ru(Py3PO)(bpy)(OH2)] 2+ (bpy is 2,20-bipyridine) is a pH-dependent water oxidation electrocatalyst that accelerates dramatically with increasing pH—up to 780 s 1 at pH 10 ( 1 V overpotential). Despite retaining the pentakis(pyridine) ligand arrangement common to previously reported catalysts, the tripodal Py3PO ligand framework supports much f...

The 3.0-A-resolution x-ray structure of rat liver 3 alpha-hydroxysteroid dehydrogenase/dihydrodiol dehydrogenase (3 alpha-HSD, EC 1.1.1.50) was determined by molecular replacement using human placental aldose reductase as the search model. The protein folds into an alpha/beta or triose-phosphate isomerase barrel and lacks a canonical Rossmann fold for binding pyridine nucleotide. The structure ...

The inside cover picture, designed by Fabrice Goursaud, holder of a PhD in organic chemistry and recently graduated from art school, illustrates the stereoselective synthesis tetrahydro[2,3-b]pyridine frameworks via one-pot metal-organo relay catalysis. strategy, which involves gold-catalyzed cycloisomerization chiral amine mediated cycloaddition reaction, provides targeted molecules yields ran...

Four novel polypyridine cobalt(II) complexes were developed based on a hexadentate ligand scaffold bearing either electron-withdrawing (−CF3) or electron-donating (−OCH3) groups in different positions of the ligand. Experiments and theoretical calculations combined to perform systematic investigation effect modification hydrogen evolution reaction. The results indicated that position, rather th...

T HE DISCOVERY OF CHANGES in the metabolism of malignant cells, as demonstrated by enzymologic technics, will lead, hopefully, to the better understanding of the nature of the neoplastic process, which is the ultimate necessity for satisfactory therapy. In 1963, Silber, Huennekens, and Gabrio1 reported the presence of increased amounts of two pyridine nucleotide transhydrogenase enzymes in huma...