While the molecular and biophysical mechanisms underlying cell protrusion on two-dimensional substrates are well understood, our knowledge of the actin structures driving protrusion in three-dimensional environments is poor, despite relevance to inflammation, development and cancer. Here we report that, during chemotactic migration through microchannels with 5 μm × 5 μm cross-sections, HL60 neu...

The paper reports a new method for three-dimensional observation of the location of focused particle streams along both the depth and width of the channel cross-section in spiral inertial microfluidic systems. The results confirm that particles are focused near the top and bottom walls of the microchannel cross-section, revealing clear insights on the focusing and separation mechanism. Based on...

The increased circuit density on today’s computer chips is reaching the heat dissipation limits for air-cooling technology. The direct liquid cooling of chips is being considered as a viable alternative. This paper reviews liquid cooling with internal flow channels in terms of technological options and challenges. The possibilities presented herein indicate a fourto ten-fold increase in heat fl...

the transport of dissolved contaminants in groundwater is usually described by the advectiondispersion equation with reaction. several numerical methods for solving the one-dimensional are availableincluding finite difference methods, finite volume methods, and finite element methods. stringent conditions,such as small peclet (pe) and courant (cr) numbers, must be satisfied to ensure the accura...

Highlights Various cross-sectional bionic microchannels were fabricated by P µ SL based 3D printing technique. Strong precursor effects are induced sharp corners of those microchannels. Ultra-long distance antigravity step lifting water is realized employing Mimicked transpiration on well achieved.

T h i s paper describes C A B O T , a case-based syst e m t h a t is able to ad jus t i ts re t r ieva l and adapt a t i o n met r ics , in a d d i t i o n to s to r ing cases. I t has been app l ied to the game of OTHELLO. Exper iments show t h a t C A B O T saves a b o u t ha l f as many cases as s imi la r systems t h a t do no t ad jus t the i r re t r ieva l and a d a p t a t i o n mechani...

We report the self-assembly of insulin monomers into amyloid fibrils within microchannels. To demonstrate the microfluidic amyloid formation and fibril growth on a solid surface, we seeded the internal surfaces of the microchannels with insulin monomers via N-hydroxysuccinimide ester activation and continuously flushed a fresh insulin solution through the microchannels. According to our analysi...