Oxidative stress in allergic asthma may result from oxidase activity or proinflammatory molecules in pollens. Signaling via TLR4 and its adaptor Toll-IL-1R domain-containing adapter inducing IFN-β (TRIF) has been implicated in reactive oxygen species-mediated acute lung injury and in Th2 immune responses. We investigated the contributions of oxidative stress and TLR4/TRIF signaling to experimen...

Article history: Received: 23 Apr 2011 Accepted: 26 Feb 2012 Available online: 18 Nov 2012 ZJRMS 2013; 15(5): 1-5 Background: Recent studies have shown that normobaric hyperoxia compared with normobaric normoxia can reduce the damages resulting from the stroke. The purpose of this study is to investigate the effects of oxygen radicals in reduction of cerebral edema caused by normobaric hyperoxi...

The diaqua complex [Pt(2-methylthiomethylpyridine)(OH(2))(2)](2+), Pt(mtp), was synthesized and investigated thermodynamically as well as kinetically. Spectrophotometric acid-base titrations were performed to determine the pK(a) values of the two coordinated water ligands. A low pK(a1) value of 3.15 was observed for the water molecule trans to the pyridine donor, whereas a pK(a2) value of 6.84 ...

The rate of substitution of aqua ligands by three nucleophiles, thiourea (TU), N,N-dimethylthiourea (DMTU) and N,N,N,N-tetramethylthiourea (TMTU), for the complexes [cis-{PtOH2(NH3)2}2-μ-pyrazine](ClO4)2 (pzn), [cis-{PtOH2(NH3)2}2-μ-2,3-dimethylpyrazine](ClO4)2 (2,3pzn), [cis-{PtOH2(NH3)2}2-μ-2,5-pyrazine](ClO4)2 (2,5pzn) and [cis-{PtOH2(NH3)2}2-μ-2,6-dimethylpyrazine](ClO4)2 (2,6pzn) was inves...

Substitution reactions of the complexes [Pd(bpma)(H2O)]2+ and [Pt(bpma)(H2O)]2+, where bpma = bis(2-pyridylmethyl)amine, with TU, DMTU and TMTU for both complexes and Cl-, Br-, I- and SCN- for the platinum complex, were studied in aqueous 0.10 M NaClO4 at pH 2.5 using a variable-temperature stopped-flow spectrophotometer. The pKa value for the coordinated water molecule in [Pd(bpma)(H2O)]2+ (6....