نتایج جستجو برای: dipeptidyl peptidase
تعداد نتایج: 10576 فیلتر نتایج به سال:
beauveria spp. as entomopathogenic fungi have extremely diverse insect host ranges.here, a comparative transcript analysis of a bassiasin i (bsni), a dipeptidyl peptidase (dpp), a cytochrom p450 monooxygenase (cyp52), a mitogen activated protein kinase (mapk), and a neuronal calcium sensor 1 (ncs) in two isolates of beauveria bassiana., with low and high virulence, were carried out. for this, i...
the proline-rich β-casein was digested in vitro with trypsin, and the oligopeptides producedwere then isolated by rp-hplc and subsequently identified by amino acid analysis and ion massspectrometry. the peptide fractions from the complete digestion were then treated with purified x-prolyldipeptidyl peptidase (x-pdp) extracted from lactobacillus casei ssp. casei llg. two bitter peptides (f53-97a...
BACKGROUND The incretin hormone, glucagon-like peptide-1, promotes myocardial glucose uptake and may improve myocardial tolerance to ischemia. Endogenous glucagon-like peptide-1 (7-36) is augmented by pharmacological inhibition of dipeptidyl peptidase-4. We investigated whether chronic dipeptidyl peptidase-4 inhibition by sitagliptin protected against ischemic left ventricular dysfunction durin...
Purpose: To explore the antidiabetic potential of Moringa oleifera leaf extract in type 2 diabetic rats, and underlying mechanisms.Methods: Streptozotocin (STZ) at a dose 40 mg/kg was given to high fat diet (HFD)- fed rats induce diabetes. M. doses 100, 200 400 were 3 groups rats. The area under curve (AUC) glucose homeostasis model assessment insulin resistance (HOMA-R) calculated using approp...
A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain. Structure activity relationships (SARs) were established using three, eleven and twelve variations respectively at the P1, P2 and P3 positions. A Ki value of 16 nM was observed for the most potent of these inhibitors which refl...
Copy right © 2013 This is an Open Access article distributed under the terms of the Indo American journal of Pharmaceutical Research, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ARTICLE INFO ABSTRACT Article history Received 31/10/2013 Available online 28/11/2013
Dipeptidyl peptidase-4 (DPP-4) is a target to treat type II diabetes mellitus. Therefore, it is important to understand the structural aspects of this enzyme and its interaction with drug candidates. This study involved molecular dynamics simulations, normal mode analysis, binding site detection and analysis of molecular interactions to understand the protein dynamics. We identified some DPP-4 ...
Dipeptidyl peptidase IV converts neuropeptide Y(1-36) (Y(1)-receptor agonist released from renal sympathetic nerves) to neuropeptide Y(3-36) (selective Y(2)-receptor agonist). Previous studies suggest that Y(1), but not Y(2), receptors enhance renovascular responses to angiotensin II in kidneys from genetically-susceptible animals. Therefore, we hypothesized that inhibition of dipeptidyl peptid...
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