Deformable image registration (DIR) and interobserver variation inevitably intro-duce uncertainty into the treatment planning process. The purpose of the current work was to measure deformable image registration (DIR) errors and interobserver variability for regions of interest (ROIs) in the head and neck and pelvic regions. Measured uncertainties were combined to examine planning margin adequa...

BACKGROUND To evaluate the geometrical differences of target volumes propagated by deformable image registration (DIR) and rigid image registration (RIR) to assist target volume delineation between diagnostic Positron emission tomography/computed tomography (PET/CT) and planning CT for primary esophageal cancer (EC). METHODS Twenty-five patients with EC sequentially underwent a diagnostic F-f...

Dopaminergic neurons of the ventral tegmental area are important components of brain pathways related to addiction. Prolonged exposure of these neurons to moderate concentrations of dopamine (DA) decreases their sensitivity to inhibition by DA, a process called DA-inhibition reversal (DIR). DIR is mediated by phospholipase C and conventional subtype of protein kinase C (cPKC) through concurrent...

BACKGROUND AND PURPOSE Accurate detection and classification of purely intracortical lesions in multiple sclerosis (MS) are important in understanding their role in disease progression and impact on the clinical manifestations of the disease. However, detection of these lesions with conventional MR imaging remains a challenge. Although double inversion recovery (DIR) has been shown to improve t...

BACKGROUND Commonly used methods of assessing the accuracy of deformable image registration (DIR) rely on image segmentation or landmark selection. These methods are very labor intensive and thus limited to relatively small number of image pairs. The direct voxel-by-voxel comparison can be automated to examine fluctuations in DIR quality on a long series of image pairs. METHODS A voxel-by-vox...

We present the CIFFWEB system, an innovative tool for the verification of web sites, relying upon abductive logic programming. The system allows the user to define rules that a web site should fulfill by using (a fragment of) the query language Xcerpt. The rules are translated into abductive logic programs with constraints and their fulfillment is checked through the CIFF abductive proof proced...

Previous studies comparing phase sensitive inversion recovery (PSIR) to double inversion recovery (DIR) have demonstrated that use of PSIR improves cross-sectional in vivo detection of cortical lesions (CL) in multiple sclerosis. We studied the utility of PSIR in detection/characterization of accrual of CL over time in a 1-year longitudinal study in primary progressive multiple sclerosis (PPMS)...

This technical report presents the work which has been carried out using Distributed Information Retrieval methods for federated search of patent documents for the passage retrieval starting from claims (patentability or novelty search) task. Patent documents produced worldwide have manuallyassigned classification codes which in our work are used to cluster, distribute and index patents through...

This paper considers alternative directory protocols for providing cache coherence in shared-memory mul-tiprocessors with 32 to 128 processors, where the state requirements of Dir N may be considered tootate (also called superset), Coarse Vector, and three new protocols. The new protocols|Gray-hardware, Gray-software, Home|are optimizations of Tristate that use gray coding to favor near-neighbo...

BACKGROUND Optimizing scan parameters for double inversion recovery (DIR) sequences remains difficult. OBJECTIVE To evaluate a new method for optimizing DIR sequence scan parameters using T1 mapping and a newly developed analysis algorithm. METHODS Twelve healthy volunteers underwent T1 mapping and DIR magnetic resonance imaging. The following steps were used for image optimization includin...