A series of novel isatin-linked 4,4-dimethyl-5-methylene-4,5-dihydrothiazole-2-thiols (IT2Ts) 1a–1g were designed as acetylcholinesterase (AChE) inhibitors capable interacting with both the catalytic active site (CAS) and peripheral anionic (PAS) enzyme simultaneously. The target IT2Ts prepared through a short synthesis in moderate yield. most potent this 1b 1c (IC50 = 18.2 27.5 μM, respectivel...

in the present study the distribution of rubella hemagglutination inhibition (hi) antibody titer in the sera of 1486 women of 18 to 25 years old residing in tehran were examined. sera were pretreated with acid washed kaolin and pigeon red blood cell. titers below 1:10 and in some studies below 1:20 are considered nonimmune to rubella. our results show that 10, 29% of studied population had hi a...

Objective(s):Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in drug resistance. Therefore, we evaluated the effects of novel approaches including siRNA directed against BCRP and targeted t...

Memory is the cognitive ability that allows acquiring, store and recalling information. Anterior thalamic dysfunction creates memory deficits in rats and humans. Anterior thalamus forms a memory network in connection with the hippocampus. This connectivity profile proposes that ventrolateral and anterior thalamus may display a nexus between reminder and control functions, such as action or atte...

objectives: goal-directed subsidies because of its nature can affect all aspects of iranian life. this scheme is not only an economic program but also affects other aspects of social life including: welfare and economic situation of society, labor market, income, expenditure and consumption pattern models of family and social problems such as poverty and inequality, drug abuse, family problem, ...

introduction: working in the complex and ever changing healthcare settings forces the nurses and nursing students to be equipped with lifelong learning skills. one of the lifelong learning skills is self-directed learning. this study aimed to explore the m.sc. nursing students’ self-directed learning activities. methods: a qualitative design using conventional content analysis approach was used...