inflammatory bowel disease (ibd) is a chronic disease of unknown etiology, in which genetic factors, seem to play an important role in the disease predisposition and course. assessment of tumor necrosis factor (tnf-α) gene polymorphisms in many populations showed a possible association with ibd. considering the genetic variety in different ethnic groups, the aim of the present study was to inve...

Accumulation of genetic data in the field Parkinson's disease research culminated identifying risk factors and confident prediction occurrence. To find new gene-targets for diagnostics therapy we have to reconstruct gene network disease, cluster genes network, reveal key (hub) with largest number interactions network. Using on-line bioinformatics tools OMIM, PANTHER, g:Profiler, GeneMANIA, STRI...

Objective(s):Brucellosis is a well-known domestic animal infectious disease, which is caused by Brucella bacterium. GroEL antigen increases Brucella survival and is one of the major antigens that stimulates the immune system. Hence, the objective of the present study was cloning and bioinformatics analysis of GroEL gene. Materials and Methods: The full-length open reading frame of this gene was...

due to the heterogeneous nature of granular soils and the involvement of many effective parameters in the geotechnical behavior of soil-foundation systems, the accurate prediction of shallow foundation settlements on cohesionless soils is a complex engineering problem. in this study, three new evolutionary-based techniques, including evolutionary polynomial regression (epr), classical genetic p...

Along with the advent of DNA microarray technology, gene expression profiling has been widely used to study molecular signatures of many diseases and to develop molecular diagnostics for disease prediction. In class prediction problems using expression data, gene selection is essential to improve the prediction accuracy and to identify informative genes for a disease. In this paper we improve t...