The current study was conducted to identify the most important variables in activation phase of cellulose acetate production. Dry alpha pulp as raw material supplied by a local company with intrinsic properties viscosity equal 926 mL/g and water content 96%. In this regard, variables, including reaction time (T30, T60, T90 min), addition level acetic acid (C25, C35, C45 units per 100 dry cellul...