Administration of the selective adenosine A1 receptor antagonist, CVT-124, to conscious chronically instrumented rats resulted in significant increases in urine flow rate and sodium excretion without affecting potassium excretion or renal hemodynamics. Its maximum effect was twice that of hydrochlorothiazide which was associated with a significant kaliuresis. The diuretic effect of CVT-124 was ...

Polyscias fruticosa (L.) Harm (Family: Araliaceae) is possibly native to Malaysia, but now widely cultivated in tropical areas and as a greenhouse plant. In Fiji, the root is used as a diuretic. The juice from the bark is taken for thrush and an ulcerated tongue or throat. A poultice made from the bark is used on syphilitic sores. The present study was undertaken to investigate diuretic effect ...

Diuretics increase the rate of urine outflow and sodium excretion and are used to adjust the volume and composition of body fluids in a variety of clinical situations including hypertension, heart failure, renal failure, nephritic syndrome and cirrhosis. Some naturally used diuretic plants are Abrus precatorius, Centella asiatica, Allium sepa, Allium sativum, Aloe barbidensis, Cinnamomum verum ...

Nyctanthes arbortristis Linn. is a well documented plant. The present study is done to establish the diuretic activity of the water-soluble portions of the ethanolic extracts of its flowers, barks, seeds and leaves. In toxicity study, the extracts were seen to be safe up to the dose of 2.0 gm/kg. For the estimation of diuretic activity, the parameters studied were total urine volume and urine c...