Silibinin, a major bioactive flavonolignan in Silybum marianum, has received considerable attention in view of its anticarcinogenic activity. The present study examines its anticancer potential against 7, 12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) induced skin cancer. Male LACA mice were randomly segregated into 4 groups: Control, DMBA/TPA, Silibinin and ...

The present study designed to investigate the protective effects of [6]-shogaol on 7,12-Dimethylbenz (a)anthracene (DMBA) induced buccal pouch carcinogenesis in male golden Syrian hamsters. Oral squamous cell carcinoma was developed in left buccal pouch of hamster by painting with 0.5% of DMBA, three times in a week. We observed an altered status of apoptotic associated gene expression (P53, bc...

Our aim was to investigate the effect of Withaferin-A on bone marrow micronucleus frequency and buccal mucosa detoxication agents during 7, 12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Oral squamous cell carcinoma was developed in hamsters' buccal pouches by painting 0.5% DMBA in liquid paraffin, three times per week for 14 weeks. We observed 100% tumor forma...

The aim of the present study was to investigate the protective effect of Withaferin-A on red blood cell integrity during 7,12-dimethylbenz[a]anthracene (DMBA) induced oral carcinogenesis. The protective effect of Withaferin-A was assessed by measuring the status of glycoconjugates, membrane bound enzyme activity and red blood cell osmotic fragility. Oral squamous cell carcinoma was induced in t...

The degradation of 7,12-dimethylbenz[a]anthracene (DMBA), a carcinogenic polycyclic aromatic hydrocarbon, by cultures of Mycobacterium vanbaalenii PYR-1 was studied. When M. vanbaalenii PYR-1 was grown in the presence of DMBA for 136 h, high-pressure liquid chromatography (HPLC) analysis showed the presence of four ethyl acetate-extractable compounds and unutilized substrate. Characterization o...

Aim of the present study was to investigate the protective effect of Clerodendron inerme on cellular integrity by measuring the status of glycoconjugates, lipids, osmotic fragility, and membrane bound enzyme activity in 7,12-dimethylbenz (a) anthracene (DMBA)-induced oral carcinogenesis. Oral squamous cell carcinoma was induced in the buccal pouch of Syrian golden hamsters by painting with 0.5%...

Aim of the present study was to investigate the anticlastogenic and antigenotoxic effect of andrographolide in the bone marrow cells of golden Syrian hamsters treated with 7,12dimethylbenz(a)anthracene (DMBA). The frequency of bone marrow micronucleated polychromatic erythrocytes (MnPCEs) was used as cytogenetic end point to assess the anticlastogenic effect of andrographolide in hamsters treat...

Abstract: The aim of the present study was directed to investigate therapeutic efficacy intraperitoneally injected curcumin as anticarcinogenic treatment modality on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch(s) (HBP(s)) carcinoma. Subjects and methods: Thirty Syrian male hamsters, five weeks old, weighing 90-130g were divided into three group(s) (G(s)): A, B, C. G-A (ne...

Background: Cancer is one of leading cause death number 2 in the world,or six deaths 2018. The incidance breast cancer as much 11,6% and are 6,6% Medical plant be expacted has potential an anticancer with minimal side effects when used at correct dosage, timing it properly.
 Objectives: To determine effect garlic extract on histopathological picture female Sprague-Dawley rats induced DMBA....

Many mouse models of breast cancer have been developed that closely replicate human breast cancer subtypes at the genomic level. In order to develop vaccines that could prevent a broad spectrum of breast cancer subtypes, a combination of different spontaneous tumor models are needed. Transgenic models are available that mimic HER2+/luminal breast cancer (TgMMTV-Neu) and triple negative/basal-li...