Inflows of coloured terrestrial organic matter cause seawater browning and reduced phytoplankton production in subarctic coastal ecosystems, potentially deteriorating the nutritional quality marine food webs. We analyzed fatty-acid (FA) compositions seston zooplankton taxa Eurytemora affinis cladocerans at three locations northern Baltic Sea. At northerly locations, salinity phosphorus concentr...

Blood fatty acid status and visual function of 20 treated hyperphenylalaninemic (HPA) children, randomly allocated into two groups to receive supplementation of either long chain polyunsaturated fatty acids (LCPUFA), including docosahexaenoic acid (DHA), or placebo for 12 months, have been investigated three years after the end of the treatment. Although in the LCPUFA group blood DHA levels and...

Docosahexaenoic acid (DHA) and lutein are important nutrients for brain health. Whether there were synergistic effects of DHA on the protection against neuronal cell damage induced by oxidative stress remained unclear. The present study was designed to investigate hydrogen peroxide (H2O2)-induced challenge in PC12 cells. cells divided into different groups received H2O2 (80 μM), (20 μM)+H2O2 (2...

Decreased tissue levels of n-3 (omega-3) fatty acids, particularly docosahexaenoic acid (DHA), are implicated in the etiologies of non-puerperal and postpartum depression. This study examined the effects of a diet-induced loss of brain DHA content and concurrent reproductive status on dopaminergic parameters in adult female Long-Evans rats. An alpha-linolenic acid-deficient diet and breeding pr...

It is known that prenatal and postnatal exposure to ethanol can result in hyperactive behavior and learning disturbance in offspring. We have previously shown that docosahexaenoic acid (DHA) ameliorated hyperactivity induced by in utero ethanol exposure in rat pups. The present study is designed to clarify the effects of DHA on neurite outgrowth and gene expression of GAP-43 and SCG10, neuron s...

INTRODUCTION The relation between docosahexaenoic (DHA) and eicosapentaenoic (EPA) vs. arachidonic acid (AA) seems characterized by both synergism and antagonism. MATERIALS AND METHODS Investigate the relation between EPA+DHA and AA in populations with a wide range of EPA+DHA status and across the life cycle. EPA+DHA and AA were determined in erythrocytes (RBC; n=1979), umbilical arteries (UA...

Under condition of oxidative stress, free radical-catalyzed peroxidation docosahexaenoic acid (DHA) and adrenic (AdA) generates in vivo neuroprostanes (NeuroPs) dihomo-isoprostanes (dihomo-IsoPs), among a large number key products participating many pathophysiological processes. These non-enzymatic oxygenated metabolites display wide range biological actions (especially DHA-metabolites), some t...

Objective: To investigate whether low docosahexaenoic acid (22:6ω3; DHA) status of malnourished, mostly breastfed infants is due to low ω3-fatty acid intake via breastmilk. Methods: The fatty acid composition of the breastmilk of 8 Pakistani mothers and that of the erythrocytes (RBC) of their malnourished children was analysed. Results: The milk of the Pakistani mothers contained low percentage...

This study investigated maternal prenatal docosahexaenoic acid (DHA) intake and infant cognitive development at 22 months. Estimates for second- and third-trimester maternal DHA intake levels were obtained using a comprehensive Food Frequency Questionnaire. Infants (n = 67) were assessed at 22 months on a novel object search task. Mothers' DHA intake levels were divided into high or low groups,...