نتایج جستجو برای: dok7 gene

تعداد نتایج: 1141397  

2013
Susan Luiskandl Barbara Woller Marlies Schlauf Johannes A Schmid Ruth Herbst

Muscle-specific kinase (MuSK), a receptor tyrosine kinase, is the key player during the formation of the neuromuscular junction. Signal transduction events downstream of MuSK activation induce both pre- and postsynaptic differentiation, which, most prominently, includes the clustering of acetylcholine receptors at synaptic sites. More recently, regulated MuSK endocytosis and degradation have be...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شاهد - دانشکده کشاورزی 1391

بیماری میوه سبز مرکبات توسط باکتری سخت کشت candidatus liberobacter asiaticus ایجاد می شود که اولین بار در چین توصیف شده است و در سال 1919 با نام رسمی huanglongbing معرفی گردید. این بیماری یکی از پرخسارت ترین بیماری های مرکبات درجنوب شرقی آسیا، شبه قاره هند، آفریقای جنوبی و شبه جزیره عربستان است. این بیماری در سال 1386 از جنوب ایران گزارش گردید. برای درک مکانیسم مولکولی برهمکنش میزبان-پاتوژن از ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Alison R Amenta Hilliary E Creely Mary Lynn T Mercado Hiroki Hagiwara Beth A McKechnie Beatrice E Lechner Susana G Rossi Qiang Wang Rick T Owens Emilio Marrero Lin Mei Werner Hoch Marian F Young David J McQuillan Richard L Rotundo Justin R Fallon

The receptor tyrosine kinase MuSK is indispensable for nerve-muscle synapse formation and maintenance. MuSK is necessary for prepatterning of the endplate zone anlage and as a signaling receptor for agrin-mediated postsynaptic differentiation. MuSK-associated proteins such as Dok7, LRP4, and Wnt11r are involved in these early events in neuromuscular junction formation. However, the mechanisms r...

Journal: :JAMA neurology 2015
Roula Ghaoui Sandra T Cooper Monkol Lek Kristi Jones Alastair Corbett Stephen W Reddel Merrilee Needham Christina Liang Leigh B Waddell Garth Nicholson Gina O'Grady Simranpreet Kaur Royston Ong Mark Davis Carolyn M Sue Nigel G Laing Kathryn N North Daniel G MacArthur Nigel F Clarke

IMPORTANCE To our knowledge, the efficacy of transferring next-generation sequencing from a research setting to neuromuscular clinics has never been evaluated. OBJECTIVE To translate whole-exome sequencing (WES) to clinical practice for the genetic diagnosis of a large cohort of patients with limb-girdle muscular dystrophy (LGMD) for whom protein-based analyses and targeted Sanger sequencing ...

Journal: :iranian journal of basic medical sciences 0
lin liu department of hematology, the second affiliated hospital of kunming medical university, kunming 650101, china lin tan department of hematology, the first affiliated hospital of kunming medical university, kunming 650041, china zhenxin he department of hematology, the first affiliated hospital of kunming medical university, kunming 650041, china

objective(s): the aim of this study was to investigate the methylation status and mrna expression levels of p15, death-associated protein kinase (dapk), and suppressor of cytokine signaling-1 (socs1) genes in multiple myeloma (mm). materials and methods: the bone marrow samples of 54 mm patients were collected and the methylation status of the p15, dapk, and socs1 gene promoter regions was dete...

Journal: :iranian red crescent medical journal 0
hamid alavi majd department of biostatistics, school of paramedical sciences, shahid beheshti university of medical sciences, tehran, ir iran atefeh talebi department of biostatistics, school of paramedial sciences, students’ research committee, shahid beheshti university of medical sciences, tehran, ir iran; department of biostatistics, school of paramedial sciences, students’ research committee, shahid beheshti university of medical sciences, tehran, ir iran. tel: +98-2122707347, fax: +98-2122721150 kambiz gilany reproductive biotechnology research center, avicenna research institute, acecr, tehran, ir iran nasibeh khayyer proteomics research center, shahid beheshti university of medical sciences, tehran, ir iran

conclusions some results of the correlation coefficients are not the same with visualization. the reason may be due to the small number of data. materials and methods in the foundation-application study, we constructed two-way gene networks using nonparametric methods, such as spearman’s rank correlation coefficient and blomqvist’s measure, and compared them with pearson’s correlation coefficie...

2015
Qiushi Chen Juliane S. Müller Poh-Choo Pang Steve H. Laval Stuart M. Haslam Hanns Lochmüller Anne Dell Hans Vliegenthart

Glutamine-fructose-6-phosphate transaminase 1 (GFPT1) is the first enzyme of the hexosamine biosynthetic pathway. It transfers an amino group from glutamine to fructose-6-phosphate to yield glucosamine-6-phosphate, thus providing the precursor for uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) synthesis. UDP-GlcNAc is an essential substrate for all mammalian glycosylation biosynthetic pat...

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