QUESTION I often prescribe domperidone to women as a galactagogue starting at a dose of 30 mg and increasing the dose as needed. In March of this year, Health Canada released an advisory warning of domperidone use and abnormal heart rhythms and sudden cardiac death. Should I cap doses at 30 mg or stop prescribing domperidone all together to these women? ANSWER The Health Canada warning is bas...

We have studied the ventilatory responses to transient hyperoxia in two groups of patients (n = 10) anaesthetized with isoflurane (0.3 MAC); patients were allocated randomly to receive either domperidone or placebo orally before anaesthesia. In each patient, five two-breath oxygen tests were averaged and minute ventilation (VEinst) or mean inspiratory flow rate (VT/TI) for each post-test breath...

Marco Bustamante-Bernal MD1 Priyanka Wani MD1 Richard W. McCallum MD2 1Department of Internal Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Science Center 2Department of Internal Medicine, Division of Gastroenterology, Paul L. Foster School of Medicine, Texas Tech University Health Science Center, El Paso, TX Domperidone, first synthesized approximately 40 years ago,...

A perception of low milk supply is often cited as a reason to stop breastfeeding, though most mothers can produce more than enough with the right support and information. Domperidone may be used to promote lactation, and there is evidence to support its use. However, the many non-pharmacological ways in which a mother may be supported should be tried before considering domperidone.

background: the majority of dyspeptic patients do not have identifiable disease, which is also known as functional dyspepsia. the therapeutic approach to patients with functional dyspepsia is still a matter of debate; prokinetic agents are commonly used for symptom relief. this study aims to evaluate the efficacy of domperidone and pyridostigmine (an inhibitor of cholinesterase) in patients wit...

the present study was aimed at evaluating the possible use of inter polymer complexed (ipc) films of xanthan gum (xg) and cationic guar gum (cgg) for formulating domperidone bioadhesive films. formation of bonds between –coo¯ groups of xg and –n + (ch 3 ) 3 groups of cgg was evident in the ftir spectra of ipc films. bioadhesive strength of the films was evaluated employing texture analyser. wat...

A rapid, quantitative and optimised high-performance thin-layer chromatographic method coupled to mass spectrometry using electro spray ionization (HPTLC/ESI-MS) for the separation and quantification of dexrabeprazole and domperidone in combined capsule dosage form has been developed and validated. The formulations were separated on silica gel 60 F254 plates using a saturated mixture of toluene...

BACKGROUND Acute gastroenteritis (AGE) is a common condition among children that is frequently accompanied by vomiting. Symptomatic control of vomiting is important as it improves patient's general condition and reduces the need for intravenous therapy and hospitalization. Antiemetic agents including ondansetron and domperidone are used to provide symptomatic relief but the existing studies do ...

BACKGROUND In up to 30 percent of small bowel capsule endoscopy procedures, the capsule does not reach the cecum within recording time. A prolonged gastric transit time has been recognized as a risk factor for incomplete capsule endoscopy. The aim of this study was to analyze if a single dose of orally administered erythromycin prior to capsule endoscopy results in a higher completion rate comp...

Background/Aims. The aim of this study was to compare the effects of ursodeoxycholic acid (UDCA) alone and UDCA plus domperidone on dissolution of solitary or multiple gallstones. Methods. Fifty-three patients with cholesterol gallstones were randomized into three treatment groups: group I (n = 22) was given UDCA (15 mg/kg/day) alone and group II (n = 18) was treated with domperidone (30 mg/day...