The non-catechol, selective dopamine D2-agonist compound 3H-205-502 was used to localize dopamine D2 receptors by autoradiography after in vitro labeling of brain sections. The characteristics of the binding of this ligand to tissue sections were those expected from the labeling of dopamine D2 receptors. The binding of 3H-205-502 was inhibited selectively and stereospecifically by dopamine D2 a...

conclusions the most important factor in diagnosis is physician’s attention and clinical experience with this condition and using irlssg. results two major theories are developed regarding the pathophysiology of rls. the first one concerns central nervous system dopamine imbalance and the second one concerns intracellular iron dysregulation. the most common used pharmacologic agents in treatmen...

Abnormal dopamine signaling in brain has been implicated in several conditions such as cocaine abuse, Parkinson's disease and depression. Potent and selective dopamine transporter inhibitors may be useful as pharmacological tools and therapeutic agents. Simple substituted pyridines were discovered as novel dopamine transporter (DAT) inhibitors through pharmacophore-based 3D-database search. The...

Parkinson's disease is a complex neurodegenerative disorder characterized by the death of brain dopamine neurons. In mammals, dopamine neuronal degeneration can be triggered through exposure to neurotoxins accumulated by the presynaptic dopamine transporter (DAT), including 6-hydroxydopamine (6-OHDA) and 1-methyl-4-phenylpyridinium. We have established a system for the pharmacological and genet...

The effects of putative retinal neurotransmitters and several neuropeptides on 3H-dopamine release from isolated perfused carp (Cyprinus carpio) retinas were studied. Of the transmitter candidates tested, only serotonin (5-HT) and the 5-HT agonist tryptamine released 3H-dopamine. However, the release evoked by these agents was calcium (Ca2+) independent and not blockable by the 5-HT antagonist ...

Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport, vascular smooth muscle contractility and production of reactive oxygen species and by interacting with the renin-angiotensin and sympathetic nervous systems. Dopamine receptors are classified into D(1)-like (D(1) and D(5)) and D(2)-like (D(2), D(3) and D(4)) subtypes based on their st...

PROGRESS TOWARDS DEVELOPMENT OF MULTIFUNCTIONAL, DOPAMINED2/D3 RECEPTOR AGONISTS AS SYMPTOMATIC AND DISEASE-MODIFYINGTHERAPEUTIC AGENTS FOR PARKINSON’S DISEASE

Evidence from psychopharmacological research has revealed that dopamine receptor agents have opposite effects on cognitive function depending on baseline levels of working memory capacity. These contrasting effects have been interpreted to reflect differential baseline levels of dopamine. Here we demonstrate for the first time that working memory capacity as measured by listening span predicts ...

INTRODUCTION A large part of research into drug addiction focuses on mesolimbic dopamine circuitry; however, both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and/or kainate and dopamine D2 receptors can play a role in maintaining the established addiction. CASE PRESENTATION We report the case of a 34-year-old man who compulsively smoked 80 to 100 cigarettes each day. After receiv...

in this study, the influence of dopamine receptor agonists and antagonists on antinociception induced by bac10fen has been examined in the formalin test. the gaba-b agonist bac10fen induced antinociception in both phases of the formalin test in mice. the dopamine receptor agonists skf 38393 and quinpirole also induced antinociception in both phases of the test. skf 38393 but not quinpirole pote...