In many applications, an ability of liposomes to retain drug and then rapidly release it at some later time would be of benefit. In this work, we investigate the ability of cationic large unilamellar vesicles (LUV) to promote rapid release of doxorubicin from anionic LUV. It is shown that the addition of cationic liposomes containing cholesterol, dioleoylphosphatidylethanolamine (DOPE), distear...

We developed a series of statistical potentials to recognize the native protein from decoys, particularly when using only a reduced representation in which each side chain is treated as a single C(beta) atom. Beginning with a highly successful all-atom statistical potential, the Discrete Optimized Protein Energy function (DOPE), we considered the implications of including additional information...

Complexes of cationic liposomes with DNA are promising tools to deliver genetic information into cells for gene therapy and vaccines. Electrostatic interaction is thought to be the major force in lipid-DNA interaction, while lipid-base binding and the stability of cationic lipid-DNA complexes have been the subject of more debate in recent years. The aim of this study was to examine the complexa...

A one-step, mild procedure based on coaxial electrospinning was developed for incorporation and controlled release of two model proteins, BSA and lysozyme, from biodegradable core-shell nanofibers with PCL as shell and protein-containing PEG as core. The thickness of the core and shell could be adjusted by the feed rate of the inner dope, which in turn affected the release profiles of the incor...

polyvinylidene fluoride/polyvinylpyrrolidone (pvdf/pvp) hollow fiber membranes were fabricated by dry-jet wet-spinning process. the correlated effects of the air gap length and pvp concentration ((1) the air gap length effect at the low and high pvp concentration in the dope solutions, as well as (2) the effect of the pvp concentration at the same air gap length) on the cross-section structure ...

Background. There are many examinations of doping in individual sports but less so team sports. Methods. A simple decision theoretic model is constructed and analysed for the incentives decisions member professional Results. Depending on detection probability punishment dopers, members do not dope at all, a medium or maximal level. The whole has higher incentive than an that least some its dope...