UNLABELLED Shivering is a frequent complication in the postoperative period. The relative efficacy of interventions that are used for the treatment of postoperative shivering is not well understood. We performed a systematic search (MEDLINE, EMBASE, Cochrane Library, hand searching, all languages, to August, 2000) for full reports of randomized comparisons of any pharmacological antishivering i...

conclusions the results of this study showed that ketamine, doxapram and meperidine are equally effective in the prevention of postoperative shivering. background postanaesthetic shivering is one of the most common unpleasant complications in patients. objectives the aim of this study was to compare the efficacy of doxapram, ketamine and meperidine in prevention of shivering after anaesthesia. ...

A study of the analeptic properties of doxapram hydrochloride, as judged by its effects on the depression induced by moderate doses of thiopentone, was carried out in sixty patients. Three dose levels of the drug were employed, all of which produced marked increases in alveolar ventilation. These increases were due almost entirely to effects on tidal volume. Although the initial peak of stimula...

Abstract Background A few years ago, the TASK-1 channel has been established as a potential new target for therapy of atrial fibrillation (AF). In heart, is almost exclusively expressed in atria and significantly upregulated AF patients. Therefore, it plays an important role shortening action observed during AF, making promising therapy. This could be proven porcine model persistent which intra...