Background Antituberculosis drugs (ATD) is the most common cause of drug-induce liver injury in many countries. While the mechanism of ATD-induced hepatitis is poorly understood, oxidative stress is suggested to be involved in the development of liver injury to drug metabolites. In this regards, we explored the possible associations between glutathione related enzymes (GCLM, GCLC and GSTP1) gen...

1. Björnsson E, Talwalkar J, Treeprasertsuk S, Kamath PS, Takahasi N, Sanderson S, et al. Drug-induced autoimmune hepatitis: clinical characteristic and prognosis. Hepatology. 2010;51:2040–8. 2. Alla V, Abraham J, Siddiqui J, Raina D, Wu GY, Chalasani NP, et al. Autoimmune hepatitis triggered by statins. J Clin Gastroenterol. 2006;40:757–61. 3. Czaja AJ. Drug-induced autoimmune-like hepatitis. ...

D-Galactosamine is one among the most experimentally used drug to study hepatotoxic effects in experimental animals. The model system of liver damage produced by D-galactosamine rats recognized be much like viral hepatitis humans from both morphological and functional points view. It also causes oxidative stress rats. Ajaswagandhadhi Lehyam has ingredients that reduce stress. This deals antioxi...

An increasing number of patients with chronic hepatitis B infection are being treated with the newly licensed drug, adefovir. It is an acyclic nucleoside phosphonate that is relatively safe in the dosage generally used for chronic hepatitis B. Serious adverse cutaneous drug reactions like Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) following adefovir use have not been rep...

conclusions in comparison with the rate of hbcab positivity reported in other iranian studies, the rate was higher in the present study. there were a few variations, genotypes, and subtypes among the infected injecting drug users. further investigations are needed to unravel the molecular characterization of obi. results sixty-four (28%) participants were hbcab positive, 59 cases were hbcab pos...

background there is still no suitable mice model that can completely mimic the human fulminant hepatitis, which sets a block for drug effect evaluation and mechanism researching of human fulminant hepatitis. objectives the aim of this study was to establish an animal model able to mimic the main features of human fulminant hepatitis. materials and methods dimethylnitrosamine (dmn) was peritonea...

Drug rash with eosinophilia and systemic symptoms syndrome (DRESS) is a rare but serious hypersensitivity drug reaction most frequently associated antiepileptics. We report case of carbamazepine-induced DRESS in 61-year-old man who was recently initiated on carbamazepine (6 weeks back) presented history acute febrile illness 10 days duration. General examination showed multiple erythematous coa...

Antituberculosis drug-induced hepatotoxicity is quite common. However, factors predicting its development are still controversial. The objective of the present study was to evaluate the role of certain factors (age and sex of the patient, alcoholism, chronic liver disease, hepatitis B virus carrier status, acetylator status, nutritional status and antituberculosis treatment (ATT) regimen) in pr...

INTRODUCTION Drug-related hepatotoxicity is a common medical problem with implications for health systems. It constitutes a cause of acute liver failure and, in many cases, is responsible for the rejection of new pharmacological agents during efficacy and safety studies. Risk factors, as well as pathogenesis of drug-induced liver injury, are poorly understood. The diagnosis of drug-induced live...

emerging new medications in the treatment of hbv produces hope and promises for curing of hbv. over the past decade, the development of oral nucleoside/nucleotide analogs (nas) with favorable potencies and tolerabilities has led to substantial advances in chronic hepatitis b (chb) therapy. the oral anti-hbv agents currently approved are lamivudine, adefovir dipivoxil , entecavir , telbivudine, ...