The increased survival of small neonates with hyaline membrane disease has led to an increase in patent ductus arteriosus in such neonates. Durirng the period of this study patent ductus arteriosus occurred in 21 % of all newborn infants who weighed <2500 g, and were seen at this hospital; the proportion increased with decreasing birthweight and gestational age.1 Patent ductus arteriosus often ...

Hallidie-Smith, K. A. (1972). Archives of Disease in Childhood, 47, 725. Murmur of persistent ductus arteriosus in premature infants. A longterm survey of the repeated clinical examination of premature newborn infants is reported. There were 52 infants in whom there was well-documented clinical and phonocardiographic evidence of delayed closure of the ductus arteriosus. The ductus is believed t...

In this retrospective study, 510 infants and children with patent ductus arteriosus (PDA) who underwent surgery at the Shahid Rajai Heart Hospital in Tehran were evaluated to determine the rate of surgical complications, morbidity and mortality. 30 patients (6%) developed minor to major complications postoperatively. Four patients who had undergone PDA ligation without division required reo...

The present study was designed to investigate the effect of O2 on intracellular Ca concentration ([Ca]i) in the ductus arteriosus and the mechanisms for O2-induced ductal contraction. The force of isometric contraction of the ring of the ductus arteriosus isolated from fetal rabbits at 30 days of gestation (term, 31 days) was measured. The ductus arteriosus was loaded with fura 2, a calcium-sen...

Nonselective cyclooxygenase (COX) inhibitors are potent tocolytic agents; however, they also have adverse fetal effects such as constriction of the fetal ductus arteriosus. Recently, selective COX-2 inhibitors have been used in the management of preterm labor in the hope of avoiding fetal complications. However, both COX-1 and -2 are expressed by cells of the ductus arteriosus. We used fetal la...

Reopening of the ductus arteriosus after successful indomethacin-induced closure has become a major problem with indomethacin treatment. In full-term human newborns and lambs, the ductus behaves like ischemic tissue after its initial constriction. Its ability to continue to relax or contract depends on the amount of left-to-right shunt through the ductus lumen. To see if ductus constriction in ...

Reopening of the ductus arteriosus after successful indomethacin-induced closure has become a major problem with indomethacin treatment. In full-term human newborns and lambs, the ductus behaves like ischemic tissue after its initial constriction. Its ability to continue to relax or contract depends on the amount of left-to-right shunt through the ductus lumen. To see if ductus constriction in ...

Takahashi, Yasushi, Christine Roman, Sylvain Chemtob, Mary M. Tse, Emil Lin, Michael A. Heymann, and Ronald I. Clyman. Cyclooxygenase-2 inhibitors constrict the fetal lamb ductus arteriosus both in vitro and in vivo. Am J Physiol Regulatory Integrative Comp Physiol 278: R1496– R1505, 2000.—Nonselective cyclooxygenase (COX) inhibitors are potent tocolytic agents; however, they also have adverse ...

Reopening of the ductus arteriosus after successful indomethacin-induced closure has become a major problem with indomethacin treatment. In full-term human newborns and lambs, the ductus behaves like ischemic tissue after its initial constriction. Its ability to continue to relax or contract depends on the amount of left-to-right shunt through the ductus lumen. To see if ductus constriction in ...

A patent ductus arteriosus, very common in the preterm infant (incidence up to 70% in infants less than 28 weeks gestational age), causes a left-to-right shunt leading to overload of the pulmonary circulation and low systemic blood flow. These hemodynamic anomalies are associated with a higher incidence of respiratory, neurological, and digestive complications of prematurity, as well as a highe...