Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-dependent cell-cell adhesion molecules which play an important role in the cell...

Background: Pemphigus vulgaris (PV) is associated with autoantibodies against desmoglein (Dsg), including Dsg1 and Dsg3. However, the precise mechanism by which acantholysis occurs in response to PV-IgG effect of tacrolimus for PV remains unclear.

The mechanism of pemphigus acantholysis has been studied with an in vitro system. Freshly prepared human skin epidermal cells were incubated in F-10 medium which contained the immunoglobulin G fraction from either pemphigus serum or normal human serum. During 18-h incubation periods, the pemphigus antibody became bound to the surface of the epidermal cells, caused the destruction of 75% of the ...

white sponge nevus (wsn) is a rare hereditary dyskeratotic hyperplasia of mucous membranes. it is an autosomal dominant disorder with variable penetrance. we report a case of wsn in a healthy 21-year-old male with no history of familial involvement. a white smooth plaque with no erythema or other structural abnormalities was observed, which confirmed the diagnosis of wsn histopathologically.

Observations: Porokeratosis is a dyskeratotic disorder of the skin characterized by hyperkeratotic papule or plaque with an annular appearance and usually diagnosed easily, both histopathologically and clinically. We present a case of linear porokeratosis which was most likely suggesting the linear epidermal nevus and linear lichen planus. We observed a tiny brown border in the dermoscopic exam...