Chemical composition of the essential oils extracted from the leaves, stems, flowers and seeds of  Heracleum rechingeri Manden. were analyzed by GC and GC/MS. Twenty-four components were characterized for the leaf oil with Octyl acetate(47.2%), Octanol(15.2%) and E-caryophyllen (5.7%) as the main constituents. 25 compounds were identified in the stem oil with Elemicin (65.3%), Octyl acetate (13...

Aphids are important insect pests in temperate regions, damaging crop plants by sucking nutrients from the phloem and by transmitting plant viruses [1]. Chemical control of certain aphid species is becoming extremely difficult due to resistance to insecticides [2]. In this context, the development of novel pest control products that specifically target aphids is highly desirable. To this end, w...

Dalopius marginatus (L.) (Coleoptera: Elateridae) is a very common click beetle species developing in forest soils an area from southwest Europe to eastern Siberia. Here, we studied the composition of female-released sex pheromone D. using coupled gas chromatography-mass spectrometry (GC-MS). Neryl octanoate, neryl decanoate, and dodecanoate, ratio approximately 1:100:3, were only volatile comp...

Several mechanisms that utilize farnesyl pyrophosphate and nerolidyl pyrophosphate as condensing substrates have been postulated for the asymmetric condensation reaction in squalene biosynthesis. Although there is ample evidence that farnesyl pyrophosphate is a substrate for this reaction, there has been no information concerning the role of nerolidyl pyrophosphate. We have made the following o...

chemical composition of the essential oils extracted from the leaves, stems, flowers and seeds of  heracleum rechingeri manden. were analyzed by gc and gc/ms. twenty-four components were characterized for the leaf oil with octyl acetate(47.2%), octanol(15.2%) and e-caryophyllen (5.7%) as the main constituents. 25 compounds were identified in the stem oil with elemicin (65.3%), octyl acetate (13...

Despite advances in immunosuppressive regimens, acute graft-versus-host disease remains a frequent complication of allogeneic hematopoietic cell transplantation. Pathogenic donor T cells are dependent on correct attachment of small GTPases to the cell membrane, mediated by farnesyl- or geranylgeranyl residues, which, therefore, constitute potential targets for graft-versus-host disease prophyla...

The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase. Serendipitously, we also found that several predicted farnesyl diphosphate synthase inhibitors were low-micromolar inhibitors of undecaprenyl diphosphate synthase. These results are of in...

A trans-farnesyl pyrophosphate-squalene synthetase has been isolated in a soluble form from yeast extracts and purified 45fold. The molecular weight of the enzyme estimated from sucrose density gradient centrifugation and gel filtration chromatography is 426,000. Solubilization of the squalene synthetase is achieved with deoxycholate. Treatment with the detergent markedly lowers squalene synthe...

Cancer cells are more addictive to MTH1 than normal cells because of their dysfunctional redox regulations. MTH1 plays an important role to maintain tumor cell survival, while it is not indispensable for the growth of normal cells. Farnesyl phenols having a coumaroyl substitution are rather uncommon in nature. Eight farnesyl phenolic compounds with such substituent moiety (1-8), including six n...