Recently, the concept of a nonlinear σ-model over a coset space G/H was generalized to the case where the group G is an infinite-dimensional Kac-Moody group, and H its (formal) 'maximal compact subgroup'. Here, we study in detail the one-dimensional (geodesic) σ-model with G = E 10 and H = K(E 10). We reexamine the construction of this σ-model and its relation to the bosonic sector of eleven-di...

This article investigated public preferences for forest biomass based liquid biofuels, particularly ethanol blends of 10% (E10) and 85% (E85). We conducted a choice experiment study in three southern states in the United States: Arkansas, Florida, and Virginia. Reducing atmospheric CO(2), decreasing risk of wildfires and pest outbreaks, and enhancing biodiversity were presented to respondents a...

We study the hidden symmetries of the fermionic sector of D = 11 supergravity, and the role of K(E10) as a generalised ‘R symmetry’. We find a consistent model of a massless spinning particle on an E10/K(E10) coset manifold whose dynamics can be mapped onto the fermionic and bosonic dynamics of D = 11 supergravity in the near space-like singularity limit. This E10-invariant superparticle dynami...

In a previous paper we conjectured that the structure of various gauge theories as well as M-theory on T8 is encoded in a unique function Ξ on the coset E10(Z)\E10(R)/K and that this function is harmonic with respect to the E10(R) invariant metric. In this paper we elaborate on the conjecture. We discuss various mass deformations of the D-instanton integral and their realizations in Ξ. We then ...

Immunotherapy is a promising strategy for the treatment of human epidermal growth factor receptor 2 (HER2)-positive tumors. Previously, we constructed an immuno-carboxy terminal fragment of Bid (immuno-tBid) and reported its specific and effective destruction of HER2-positive tumor cells. In this study, in order to further reduce the immunogenicity of the previous immuno-proapoptotic protein, w...

Cell shape is mediated in part by the actin cytoskeleton and the actin-binding protein vinculin. These proteins in turn are regulated by protein phosphorylation. We assessed the contribution of cAMP-dependent protein kinase A isozyme I (PKA I) to lung epithelial morphology using the E10/E9 sibling cell lines. PKA I concentration is high in flattened, nontumorigenic E10 cells but low in their ro...

We previously identified an Ets cis-element in the mouse caveolin-1 promoter that is selectively activated in lung epithelial (E10), but not lung endothelial murine lung endothelial cell line (MFLM-4), cell lines and therefore appears important for differential, cell-specific caveolin-1 transcription. In the present study, we demonstrate that immunostaining of adult mouse lung detects the ETS p...

Dry eye syndrome (DES) is a common eye disease. Artificial tears (AT) are used to treat DES, but they are not effective. In this study, we assessed the anti-inflammatory effect of AT containing epigallocatechin gallate (EGCG) and hyaluronic acid (HA) on DES. Human corneal epithelial cells (HCECs) were used in the WST-8 assay to determine the safe dose of EGCG. Lipopolysaccharide-stimulated HCEC...