نتایج جستجو برای: early onset breast cancer
تعداد نتایج: 1725716 فیلتر نتایج به سال:
BACKGROUND Germline mutations in p53 are associated with the Li-Fraumeni Syndrome which is characterized by childhood cancers, including pediatric adrenal cortical carcinomas and early onset breast cancer. The high incidence of adrenal cortical carcinomas in southern Brazil is mostly attributed to the R337H mutation in TP53. The relatively high population frequency of this mutation in southern ...
Abstract Background: Breast cancer is the most common cancer among women. Polymorphisms of micro RNA genes such as microRNA 152 and microRNA 148a that they are involved in cell proliferation, angiogenesis and apoptosis could be a potential factor for increasing risk of breast cancer and its development. So, the aim of this study is to investigate the association between polymorphisms of thes...
BACKGROUND Breast cancer in young women tends to have a natural history of aggressive disease for which rates of recurrence are higher than in breast cancers detected later in life. Little is known about the genetic pathways that underlie early-onset breast cancer. Here we report the discovery of DEAR1 (ductal epithelium-associated RING Chromosome 1), a novel gene encoding a member of the TRIM ...
Introduction: Lack of a proper method for early detection and diagnostic errors in medicine are some fundamental problems in treating cancer. Data analysis techniques may significantly help early diagnosis. The current study aimed at applying and evaluating neural networks and decision tree algorithm on breast cancer patients’ data for early cancer prediction. Methods: In the current stu...
Introduction: Lack of a proper method for early detection and diagnostic errors in medicine are some fundamental problems in treating cancer. Data analysis techniques may significantly help early diagnosis. The current study aimed at applying and evaluating neural networks and decision tree algorithm on breast cancer patients’ data for early cancer prediction. Methods: In the current stu...
Breast cancer is the most common cancer in Iran. In the recent years an upward trend has been observed in the Iranian population. Early detection by molecular approaches may reduce breast cancer morbidity and mortality. We provided consultation to 3,782 women diagnosed with early onset breast cancer during the past 15 years (1999-2014). To establish a data set for BRCA gene alterations of the I...
OBJECTIVE(S) Breast cancer is the most common cancer in women. Every year, one million new cases are reported worldwide, representing 18% of the total number of cancer in women. Hereditary BRCA1 and BRCA2 mutations account for about 60% of inherited breast cancer and are the only known causes of hereditary breast cancer syndrome. The aim of this study was to determine the frequency of BRCA2 (ex...
Variation in the detection, signaling, and repair of DNA damage contributes to human cancer risk. To assess capacity to modulate endogenous DNA damage among radiologic technologists who had been diagnosed with breast cancer and another malignancy (breast-other, n=42), early-onset breast cancer (early-onset, age <or=35; n=38), thyroid cancer (n=68), long-lived cancer-free individuals (hyper-norm...
background : breast cancer, a critical health problem, is considered to be a progressive disease with a poor prognosis if detected late. public education about the disease plays a pivotal role in early detection and subsequent improvements in prognosis. the present study assesses the knowledge and awareness about various aspects of breast cancer among female university students. methods : the k...
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