purpose: to evaluate the effect of early aqueous suppressants initiation on ahmed glaucoma valve success rate. methods: in this randomized clinical trial, a total of 94 eyes of 94 patients with refractory glaucoma were enrolled. the eyes were randomly selected into 2 groups. in group 1 (n=47), patients received early topical combination of timolol-dorzolamide twice daily after ahmed glaucoma va...

Osteonecrosis of the femoral condyle is known as an uncommon complication after arthroscopic meniscectomy. The lesion of osteonecrosis can be irreversible, thus early detection of the disease is crucial for treatment. A 50-year-old male patient without known risk factors of osteonecrosis developed increasing knee pain after arthroscopic partial meniscectomy. Magnetic resonance imaging showed ra...

This is a report of a case of cornual ectopic pregnancy, with transvaginal ultrasonography done for early detection, screening, β-hCG measuring, also discussed was the role of methotrexate therapy prior to operative procedure with conservative management. Multiple intramural myomas (22 myomas) in this case were strongly believed as the etiology of the cornual pregnancy. (Med J Indones 2008; 18:...

Early-stage breast cancer is a prevalent malignancy that continues to cause a significant number of cancer-related deaths each year. Current evidence points to suboptimal care in patients with early-stage breast cancer, especially with regard to physician use of guideline-recommended care. Such appropriate treatment regimens as breast-conserving therapy and adjuvant therapy (including radiation...

BACKGROUND Treatment strategies for tight control of early rheumatoid arthritis (RA) are highly effective but can be improved. OBJECTIVE To investigate whether adding prednisone, 10 mg/d, at the start of a methotrexate (MTX)-based treatment strategy for tight control in early RA increases its effectiveness. DESIGN A 2-year, prospective, randomized, placebo-controlled, double-blind, multicen...

BACKGROUND The Combinatietherapie Bij Reumatoide Artritis (COBRA) trial has proved that combination therapy with prednisolone, methotrexate and sulphasalazine is superior to sulphasalazine monotherapy in suppressing disease activity and radiological progression of early rheumatoid arthritis (RA). In addition, 5 years of follow-up proved that COBRA therapy results in sustained reduction of the r...

are critical aspects of patient management because organ involvement is responsible for most of the complications and mortality in SSc. Clinical signs to aid early diagnosis or organ involvement have been identified (7-9), and comprehensive criteria for early diagnosis are being developed (9, 10). Furthermore, efforts to identify and validate circulating biomarkers to assess rate of progression...

BACKGROUND Malignant proliferating trichilemmal tumour is a rare skin tumour that originates from the root sheath of the hair and usually arises in the sun-exposed areas of elderly women. It mimicks poorly differential squamous cell carcinoma ant its biological behaviour is unpredictable, because rarely can produce distant metastases. CASE REPORT The Authors report on a case of a 54-year-old ...

Declining cancer incidence and mortality rates in the United States (U.S.) have continued through the first decade of the twenty-first century. Reductions in tobacco use, greater uptake of prevention measures, adoption of early detection methods, and improved treatments have resulted in improved outcomes for both men and women. However, Black Americans continue to have the higher cancer mortali...

background : prosthetic valve endocarditis (pve) is an important cause of morbidity and mortality associated with heart valve replacement surgery. the aim of the present study was to describe the early outcome of treatment in patients with pve in a single center. methods : the data of all the episodes of pve registered at our institution between 2002 and 2007 were collected and analyzed retrosp...