•IPADs are fluorescent indicators for visualizing Pcdhα4 trans-interactions•IPADs can reversibly monitor allow visualization of self-recognition in neurons Clustered protocadherin (Pcdh), a cell adhesion protein, is involved the and non-self-discrimination by conferring diversity on surface. Although roles Pcdh have been elucidated, it has challenging to visualize its activity neurons, which mo...

Both benzodiazepines and -hydroxybutyric acid (GHB) are used to treat alcohol withdrawal syndrome. The molecular basis for this therapeutic efficacy was investigated with primary cultures of rat cerebellar granule cells. Long-term exposure of these cells to ethanol (100 mM, 5 days) reduced the abundance of mRNAs encoding the 2L and 2S subunits of the GABA type A receptor ( 32 and 23%, respectiv...