نتایج جستجو برای: ece

تعداد نتایج: 1817  

Journal: :The Journal of Cell Biology 2007
Benjamin E. Padilla Graeme S. Cottrell Dirk Roosterman Stella Pikios Laurent Muller Martin Steinhoff Nigel W. Bunnett

Although cell surface metalloendopeptidases degrade neuropeptides in the extracellular fluid to terminate signaling, the function of peptidases in endosomes is unclear. We report that isoforms of endothelin-converting enzyme-1 (ECE-1a-d) are present in early endosomes, where they degrade neuropeptides and regulate post-endocytic sorting of receptors. Calcitonin gene-related peptide (CGRP) co-in...

Journal: :The Review of scientific instruments 2008
J W Oosterbeek A Bürger E Westerhof M R de Baar M A van den Berg W A Bongers M F Graswinckel B A Hennen O G Kruijt J Thoen R Heidinger S B Korsholm F Leipold S K Nielsen

An electron cyclotron emission (ECE) receiver inside the electron cyclotron resonance heating (ECRH) transmission line has been brought into operation. The ECE is extracted by placing a quartz plate acting as a Fabry-Perot interferometer under an angle inside the electron cyclotron wave (ECW) beam. ECE measurements are obtained during high power ECRH operation. This demonstrates the successful ...

Journal: :The Journal of clinical endocrinology and metabolism 1998
S Yoshioka H Fujiwara S Yamada K Tatsumi T Nakayama T Higuchi T Inoue M Maeda S Fujii

We have previously reported that membrane-bound amino- and carboxypeptidases were expressed on the human follicles and corpora lutea (CL), and we proposed that these peptidases are involved in ovarian functions, probably by regulating the extracellular peptide concentrations. In this study, we examined the expression of endothelin-converting enzyme-1 (ECE-1) on human follicles and CL, which is ...

1999
Olivier Valdenaire Alain Barret Anja Schweizer Elisabeth Rohrbacher Françoise Mongiat Florence Pinet Pierre Corvol Claude Tougard

Endothelin (ET), the most potent vasoconstricting substance known so far, was first identified in cultured endothelial cells (Yanagisawa et al., 1988). The ET family includes three peptides, ET-1, ET-2 and ET-3, encoded by distinct genes (Inoue et al., 1989) and present in a wide variety of cells and tissues (see Rubanyi and Polokoff, 1994, for review). Maturation of the ET peptides occurs in t...

Journal: :The Journal of clinical investigation 2014
Makiko Kido-Nakahara Jörg Buddenkotte Cordula Kempkes Akihiko Ikoma Ferda Cevikbas Tasuku Akiyama Frank Nunes Stephan Seeliger Burcu Hasdemir Christian Mess Timo Buhl Mathias Sulk Frank-Ulrich Müller Dieter Metze Nigel W Bunnett Aditi Bhargava Earl Carstens Masutaka Furue Martin Steinhoff

In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein-coupled receptor endothelin A receptor (ETAR). Here, we have identified neural endothelin-converting enzyme 1 (ECE-1) as a key regulator of ET-1-induced pruritus and neural si...

2013
D. David Neels Pon Kumar

Fuzzy based Priority Scheduler for WiMAX with Improved QoS constraints Prof. D. David Neels Pon Kumar Department of ECE, Einstein College of Engineering, Tirunelveli, India, Email: [email protected] Dr. K. Murugesan Professor and Head, Department of ECE , Sree Sastha Institute of Engineering, Chennai, India, Email: [email protected] Prof. K. Arun Kumar Department of ECE, Einstein Col...

Journal: :Circulation 2001
C Ihling T Szombathy B Bohrmann M Brockhaus H E Schaefer B M Loeffler

BACKGROUND Endothelin-converting enzyme (ECE)-1 activates endothelin-1 (ET-1) and may thus contribute to the regulation of vascular tone and cell growth during atherosclerosis. METHODS AND RESULTS To evaluate ECE-1 immunoreactivity concerning big ET-1/ET-1, we performed qualitative and quantitative immunohistochemistry in normal internal mammary arteries (n=10), in coronary arteries with adap...

2012
Haruya Ishiguro Shoichi Saito Hiroo Imazu Hiroyuki Aihara Tomohiro Kato Hisao Tajiri

Purpose. Although esophageal capsule endoscopy (ECE) is reportedly useful in the diagnosis of esophageal varices (EV), few reports have described the benefits of this technique in Asian countries. The present paper evaluates the usefulness of ECE for diagnosing EV in Japanese patients with cirrhosis. Methods. We examined 29 patients with cirrhosis (20 males and 9 females; mean age 60 years; Chi...

Journal: :Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 2014
Dilek Unal Arzu Oguz Arzu Tasdemir

BACKGROUND The status of the axillary lymph nodes is an important factor in the prognosis and treatment of breast cancer. Extracapsular extension (ECE) is the spread of lymphatic tumor cells beyond the capsule of an axillary lymph node. Recent studies have demonstrated that ECE is a strongly unfavorable prognostic factor. OBJECTIVE In the present study, we investigated whether the rate of met...

2018
Tanya Gurieva Mirjam J D Dautzenberg Marek Gniadkowski Lennie P G Derde Marc J M Bonten Martin C J Bootsma

Background The global emergence of infections caused by Enterobacteriaceae resistant to expanded-spectrum cephalosporins (ESCs) in intensive care units (ICUs) is, at least partly, driven by cross-transmission. Yet, individual transmission capacities of bacterial species have not been quantified. Methods In this post hoc analysis of a multicenter study in 13 European ICUs, prospective surveill...

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