Electron detachment dissociation (EDD) has previously provided stereo-specific product ions that allow for the assignment of the acidic C-5stereochemistry in heparan sulfate glycosaminoglycans (GAGs), but application of the same methodology to an epimer pair in the chondroitin sulfate glycoform class does not provide the same result. A series of experiments have been conducted in which glycosam...

The objective of this research is to develop an effective and efficient design methodology for optimizing the configurations of energy dissipation devices (EDD) based on building performance objectives. Current design codes do not provide any guidelines for the optimization of EDD configurations. Previous research efforts are either limited in addressing different performance indices or not eff...

Report of the 2013-2014 Academic Affairs Committee Jeff Cain, EdD, MS, Jeannine M. Conway, PharmD, Margarita V. DiVall, PharmD, Med, Brian L. Erstad, PharmD, Paul R. Lockman, PhD, John C. Ressler, EdD, Amy H. Schwartz, PharmD, Scott Stolte, PharmD, Ruth E. Nemire, PharmD, EdD a University of Kentucky College of Pharmacy, Lexington, Kentucky b University of Minnesota College of Pharmacy, Minneap...

To purchase reprints, contact The InnoVision Group, 101 Columbia, Aliso Viejo, CA 92656. Phone, (800) 809-2273 or (949) 362-2050 (ext 532); fax, (949) 362-2049; e-mail, [email protected]. By Mary Lou Sole, RN, PhD, CCRN, Jacqueline F. Byers, RN, PhD, CNAA, Jeffery E. Ludy, EdD, RRT, and C. Lynne Ostrow, RN, EdD. From the School of Nursing (MLS, JFB) and Cardiopulmonary Sciences (JEL), Universit...

BACKGROUND Minimal change nephritic syndrome (MCNS) is characterized by a lack of obvious abnormalities on light microscopy, but its electron microscopic findings include the negative immunofluorescence findings and the diffuse effacement of the epithelial cell foot processes. Rarely the presence of electron dense deposits (EDDs) has been reported, but its clinical significance remains obscure....

Winds play a significant role in active galactic nuclei feedback process. Previous simulations studying winds only focus on small dynamical range. Therefore, it is unknown how far the can go and what properties of will be if they move to large radii. We perform study scale dynamics driven by line force. find that depend both black hole mass ($M_{BH}$) accretion disk luminosity. When luminosity ...

The 40.5-min region of the Escherichia coli map contains the zwf gene, which encodes glucose-6-phosphate dehydrogenase, an enzyme of the pentose phosphate pathway, and the edd and eda genes, which encode 6-phosphogluconate dehydratase and 2-keto-3-deoxy-6-phosphogluconate aldolase, respectively, the key enzymes of the Entner-Doudoroff pathway (4). These three genes are tightly linked, and their...

Disulfide bonds generally show only limited cleavage in positive ion mode collision activated dissociation (CAD). However, it has been emonstrated that a reverse situation exists in negative ion mode in which preferential S S and C S bond cleavage occurs. Here, we show that lectron detachment dissociation (EDD) and infrared multiphoton dissociation (IRMPD) of peptide anions containing disulfide...

In Pseudomonas putida, genes for the glucose phosphorylative pathway and the Entner-Doudoroff pathway are organized in two operons; one made up of the zwf, pgl, and eda genes and another consisting of the edd, glk, gltR2, and gltS genes. Divergently with respect to the edd gene is the gap-1 gene. Expression from P(zwf), P(edd), and P(gap) is modulated by HexR in response to the availability of ...

OBJECTIVES We sought to assess smooth muscle function in adults at risk for atherosclerosis. BACKGROUND Previous studies in subjects at risk for atherosclerosis have demonstrated arterial endothelial dysfunction, with reduced vasodilator responses after pharmacologic or physiologic stimulation of endothelial nitric oxide (NO). Most have also shown a slight but nonsignificant impairment of vas...