Introduction: Nitric oxide seems to play a dual role in ischemia/reperfusion injury. Few studies have investigated whether it exacerbates or improves brain edema. In the present study, we inhibited the activity of nitric oxide synthase by L-NAME and evaluated the cerebral infarct volume, tissue swelling and brain edema, alongside the measurement of blood flow of the ischemic region. Methods: Tr...

• In the intact animal or man, pulmonary engorgement and edema are generally assessed on clinical and radiographic grounds. In the present study, pulmonary engorgement or a combination of pulmonary engorgement and edema was produced experimentally in anesthetized dogs and an attempt was made to distinguish between the two categories on the basis of measurements of the pulmonary blood volume, th...

Objective(s): Preclinical studies show that iron plays a key role in mediating neuronal injury. This study was performedin order to identify the relationship between the serum level of ferritin and severity of the brain injury which occur after an Intracerebral hemorrhage (ICH). Materials and Methods:This was a cross sectional descriptive – analytic study, which was conducted on those patients ...

Early hematoma enlargement and delayed clot lysis contribute to brain injury after intracerebral hemorrhage (ICH). We investigated hematoma growth, clot lysis, and brain edema formation in patients with spontaneous ICH. A total of 17 spontaneous ICH patients who received regular medication were chosen for this study. All patients had their first CT scan within 5 hours of onset of symptoms (day ...

The presence of abnormal amounts of fluid within body tissues (defined as edema) is generally considered detrimental to normal cell physiology, including wound healing following surgery . Appropriate postoperative wound management seeks to prevent, control and reduce edema. The accurate monitoring of volume changes within a given mass of tissue can indicate the amount of edema present and thus ...

the extracardiac actions of calcium-channel belockers has little been studied.in fact,it has been demonstrated in a number of in viro studies,that calcium-channel belockers are involved in inflammation.here,we evaluated the dose-dependent Effects of verapamil and nifedipine on carrageenan-induced, acute inflammation in the rat paw compared to the anti-inflammatory activites of ibuprofen.the adu...

Background & Aims: Ischemic postconditioning, conducted by a series of brief occlusion and release of the bilateral common carotid arteries, has neuroprotective properties in permanent or transient models of middle cerebral artery (MCA) occlusion but its delayed neuroprotective effects in the embolic model of stroke, especially in female rat, have not yet been reported and were investigated ...

OBJECTIVES To investigate optical coherence tomography consistency on foveal thickness, foveal volume, and macular volume measurements in patients with and without diffuse diabetic macular edema. INTRODUCTION Optical coherence tomography represents an objective technique that provides cross-sectional tomographs of retinal structure in vivo. However, it is expected that poor fixation ability, ...

background: nitric oxide synthase (nos) activity is increased during hypertension and cerebral ischemia. nos inactivation reduces stroke-induced cerebral injuries, but little is known about its role in blood-brain barrier (bbb) disruption and cerebral edema formation during stroke in acute hypertension. here, we investigated the role of nos inhibition in progression of edema formation and bbb d...

BACKGROUND The diagnostic strength of the jugular venous pressure (JVP) and pedal edema as physical examination tools for the assessment of volume status has been minimally studied. METHODS We conducted a prospective observational study in an outpatient peritoneal dialysis clinic in Saskatoon, Canada. Patients were adult (age 18 or older) peritoneal dialysis outpatients without any history of...