In this paper, a mathematical model for the strategic planning and design of supply chains in the globalization context is proposed. A multi-objective function is used to address decisions about capacity sizing, sourcing, and facility location, with the scope of maximizing supply chain profits. The model is dynamic and is applied to a multiechelon, multi-facility and multi-product supply chain ...

In this paper, we propose a procedure, based on statistical design of experiments and gradient descent, that finds effective settings for parameters found in heuristics. We develop our procedure using four experiments. We use our procedure and a small subset of problems to find parameter settings for two new vehicle routing heuristics. We then set the parameters of each heuristic and solve 19 c...