LY303366 is a semisynthetic derivative of the echinocandin class. During preclinical studies, lethal toxicity was observed in DBA/2 mice pretreated with a cortisone acetate dose followed by treatment with LY303366 at doses ranging from 12.5 to 50 mg/kg of body weight/day given intraperitoneally (i.p.). In the cortisone-treated, uninfected controls, 90% given LY303366 at 50 mg/kg died. Deaths oc...

AIM To investigate the effect of chymase on the mucin secretion from human bronchial epithelial cells. METHODS Primarily-cultured human bronchial epithelial (PCHBE) cells and normal human bronchial epithelial (NHBE) cells were cultured with chymase or other stimulus in a mixture of bronchial epithelial growth medium (BEGM) and Dulbecco's modified Eagle's medium (DMEM), and the quantities of s...

Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA) induces complete remissions in 85% of patients. Complete remission has been defined as the absence of hairy cells in the bone marrow after routine morphologic examination. To determine if hairy cells could be detected in complete remission bone marrows using immunohistochemical techniques with antibodies L26 (CD20) and DBA.44,...

The concept of school sport on which we are basing our experience is set in the Historical Territory of Bizkaia (Basque Country, Spain) and this is regulated by Bizkaia’s Diputación Foral (Provincial Council), governed by the regional regulations of the Basque Government. This government takes the view that School Sport covers sport activities at teaching centres outside actual school teaching ...

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplastic anemia, characterized by macrocytic anemia, reticulocytopenia, and severely reduced numbers of erythroid precursors in the bone marrow. For more than fifty years, glucocorticoids have remained the main option for pharmacological treatment of DBA. While continuous glucocorticoid administration increases hemoglobin levels in a ma...

According to the Ministry of Health (2006), Noise-Induced Hearing Loss (NIHL) is hearing loss caused by prolonged exposure to noise. It is characterized as sensorineural hearing loss and is usually bilateral, irreversible, and progressive while the exposure to noise continues. A NIHL is a predictable and preventable disease with an epidemiologically relevant prevalence in urban communities. The...

Siamese trackers have achieved a good balance between accuracy and efficiency in generic object tracking. However, background distractors cause side effects to the discriminative representation of target. To suppress sensitivity distractors, we propose Double Branch Attention (DBA) block tracker equipped with DBA named DBA-Siam. First, concatenates channels multiple layers from two branches fra...

Noise-induced hearing loss (NIHL) is caused by cumulative occupational and non-occupational noise exposure. The National Institute for Occupational Safety Health (NIOSH) developed exposure recommendations (85 dBA 8-hour time-weighted average) in 1972. Fifty years later, the NIOSH recommended limit (REL) needs to be revised downwards. In its calculations, assumed that workers have quiet when not...