Genetic deficiency of human purine nucleoside phosphorylase (PNP) causes T-cell immunodeficiency. The enzyme is therefore a target for autoimmunity disorders, tissue transplant rejection and T-cell malignancies. Transition state analysis of bovine PNP led to the development of immucillin-H (ImmH), a powerful inhibitor of bovine PNP but less effective for human PNP. The transition state of human...

Currently more and more agents are involved in human routine activities and a mixed human-agent society is thus formed by the humans and the agents involved. The relationship between humans and agents in this mixed society is subtle and it is vital to explore the influence that agents bring into the society. In this paper, we try to investigate a few questions: will humans act differently towar...

Let X1,X2, . . . , be independent random variables with EXi = 0 and write Sn = ∑ n i=1 Xi and V 2 n = ∑ n i=1 X i . This paper provides an overview of current developments on the functional central limit theorems (invariance principles), absolute and relative errors in the central limit theorems, moderate and large deviation theorems and saddle-point approximations for the self-normalized sum S...

one concern about using transgenic plants is the genetic variation that occurred from theirs tissue culture and regeneration. molecular markers are an important element for efficient and effective determination of genetic variation. the present work was carried out to assess the genetic uniformity of transgenic cottons (bt and chitinase lines), using rapd, issr molecular markers and sds-page an...

A cake is a metaphor for a heterogeneous, divisible good, such as land. A perfect division of cake is efficient (also called Pareto-optimal), envyfree, and equitable. We give an example of a cake in which it is impossible to divide it among three players such that these three properties are satisfied, however many cuts are made. It turns out that two of the three properties can be satisfied by ...

Fair Division, unlike most research on fairness in the social sciences and mathematics, is devoted solely to the analysis of constructive procedures for actually dividing things up and resolving disputes, including...

The direct and indirect boundary element methods, accelerated via the fast multipole method, are applied to numerical simulation of room acoustics for large rooms volume $\sim 150$ $m^{3}$ frequencies up 5 kHz on a workstation. As parameter $kD$ (wavenumber times diameter) is large, stabilization previously developed FMM algorithms required accuracy. A scheme one key contribution this paper. co...

introduction kawasaki disease (kd) is an acute systemic vasculitis, of unknown etiology, that mainly affects infants and young children. although originally thought to be a benign illness, kd may prove fatal, especially if the diagnosis is delayed due to a nonclassic presentation. case presentation here, we present the case of a 4-year-old girl with a history of prolonged fever. her physical ex...