Delivery of tumor-associated Ag-derived peptides in a high immunogenic form represents one of the key issues for effective peptide-based cancer vaccine development. We report herein the ability of nonpathogenic filamentous bacteriophage fd virions to deliver HLA-A2-restricted MAGE-A10(254-262)- or MAGE-A3(271-279)-derived peptides and to elicit potent specific CTL responses in vitro and in vivo...

BACKGROUND The roles of physicians in oral healthcare delivery are very important due to the unequal distribution of the low oral health manpower as well as the lack of awareness of patients concerning the treatment of oral health problems by dentists in Nigeria. AIM To assess the Nigerian clinical level medical students' knowledge of dental problems and conditions in relation to the dental s...

Rev Esp Cardiol 2004;57(4):279-82 279 Cardiac resynchronization therapy (CRT) is a new invasive technique. The devices used are expensive, the implantation procedure is usually lengthy, sometimes complex, and the technique is not exempt from complications. Despite these limitations, however, CRT has experienced great progress over recent years, both clinically and experimentally. To what, then,...

Ewing sarcoma is a transcription factor-mediated pediatric bone tumor caused by a chromosomal translocation of the EWSR1 gene and one of several genes in the ETS family of transcription factors, typically FLI1 or ERG. Full activity of the resulting oncogenic fusion protein occurs only after binding RNA helicase A (RHA), and novel biologically targeted small molecules designed to interfere with ...

Rev Esp Cardiol 2004;57(4):279-82 279 Cardiac resynchronization therapy (CRT) is a new invasive technique. The devices used are expensive, the implantation procedure is usually lengthy, sometimes complex, and the technique is not exempt from complications. Despite these limitations, however, CRT has experienced great progress over recent years, both clinically and experimentally. To what, then,...

Oncogenic fusion proteins, such as EWS-FLI1, are excellent therapeutic targets as they are only located within the tumor. However, there are currently no agents targeted toward transcription factors, which are often considered to be 'undruggable.' A considerable body of evidence is accruing that refutes this claim based upon the intrinsic disorder of transcription factors. Our previous studie...