bottom-up approaches have emerged as promising alternatives for generation of organized nanostructures and electronic components. [ 4 ] Bottom-up techniques generally rely upon molecular self-assembly phenomena to produce defi ned structures that could be practically utilized. [ 5 , 6 ] Here, we describe a new bottom-up approach for construction of thin-fi lm TCEs through self-assembly of alkyl...

Azacytidine is an established nucleoside drug that is well known for its ability to modulate epigenetic gene regulation by inhibition of DNA methylation. Despite recent advances in the clinical development of azacytidine, the use of the drug is limited by its low bioavailability and dependency on variably expressed nucleoside transporters for cellular uptake. We show here that CP-4200, an elaid...

Epidemiological studies suggest that chronic consumption of trans MUFA may alter muscle insulin sensitivity. The major sources of dietary trans MUFA (dairy fat vs. industrially hydrogenated oils) have different isomeric profiles and thus probably different metabolic consequences. These effects may involve alterations in muscle mitochondrial oxidative capacity, which may in turn promote insulin ...

The presence or absence of unsaturation in the carbon chain carboxylic acids was examined on friction response boundary films according to normal force. Friction laws were established as a function force at nanoscale with molecular tribometer derived from surface apparatus. While shear plane is mainly composed methyl groups all cases investigated, organization differs within plane, suggested by...

The matrix metalloproteinases gelatinase A (MMP-2) and gelatinase B (MMP-9) are implicated in the physiological and pathological breakdown of several extracellular matrix proteins. In the present study, we show that long-chain fatty acids (e.g. oleic acid, elaidic acid, and cis- and trans-parinaric acids) inhibit gelatinase A as well as gelatinase B with K(i) values in the micromolar range but ...

In synaptosomal brain membranes, the addition of oleic acid (cis), elaidic acid (trans), and the cis and trans isomers of vaccenic acid, at a concentration of 0.87 mumol of lipid/mg of protein, strongly reduced the Bmax and, to a lesser degree, the binding affinity of the mu-selective opioid [3H]Tyr-D-Ala-Gly-(Me)Phe-Gly-ol ([3H]DAMGO). At comparable membrane content, the cis isomers of the fat...

The Phlomis bracteosa oil constituents of methyl ester derivatives of fatty acids were analyzed using Gas Chromatography coupled to mass spectrometer. The results obtained containing the saturated as well as unsaturated fatty acids of P. bracteosa oils. A total of 18 different components were identified and quantified. Methyl ester of octadecadienoic acid was found in high concentration 6.88 %,...