A computer simulation of the extracellular field potential recording of nerve activity is presented. An experimental setup composed of an oscilloscope, a nerve, a conductive surface, and a recording electrode is graphically simulated. The user may study the influence of the position of the recording electrode and of certain nerve properties (membrane potential, velocity of conduction and action...

Spike sorting is a class of techniques used in the analysis of electrophysiological data. Studying the dynamics of neural activity via electrical recording relies on the ability to detect and sort neural spikes recorded from a number of neurons by the same electrode. This article reviews methods for detecting and classifying action potentials, a problem commonly referred to as spike sorting.

At a procedural level, in vivo whole-cell patch-clamp recording is very similar to the in vitro technique (see UNITS 6.6, 6.7, & 6.10), though there are important differences. Unlike the typical in vitro recording situation for mammalian preparations, one cannot utilize Differential Interference Contrast (DIC) optics to visualize neurons or the recording electrode in vivo, nor can the experimen...

AB STRAC'T A multipolar split cuff electrode is used for fascicle selective recording of the electroneurogram (ENG) of the sciatic nerve of the rabbit. Several electrode configurations were evaluated with regarding to seleclivity: the peroneal and tibial nerves were stimulated alternately and the ENG was recorded at different sides of the sciatic nerve. The results for two electrode configurati...

Continuous recording of ruminal pH in cannulated cattle has been practiced to study rumen metabolism. However, most systems reported did not permit animal mobility during pH recording. Therefore, the objective of this study was to develop a continuous rumen pH data acquisition system that permitted animal mobility during data acquisition. A further objective was to compare the pH readings obtai...

Deep brain stimulation (DBS) is a common therapy for treating movement disorders, such as Parkinson's disease (PD), and provides a unique opportunity to study the neural activity of various subcortical structures in human patients. Local field potential (LFP) recordings are often performed with either intraoperative microelectrodes or DBS leads and reflect oscillatory activity within nuclei of ...

OBJECTIVES Bilateral chronic high frequency stimulation of the subthalamic nucleus (STN), through the stereotactical placement of stimulating electrodes, effectively improves the motor symptoms of severe Parkinson's disease. Intraoperative neurophysiological and clinical monitoring techniques (neuronal electrical activity recording and intraoperative stimulation) may improve and refine the loca...

OBJECTIVE To derive normative values for ulnar nerve conduction study of the active recording electrode on the first dorsal interosseous muscle (FDI) and the reference electrode on the proximal phalanx of the thumb. METHOD Ulnar nerve motor conduction study with FDI and abductor digiti minimi muscle (ADM) recording was performed in 214 hands of 107 healthy subjects. Ulnar NCS was performed wi...

Multielectrode arrays have enabled electrophysiological experiments exploring spatio-temporal dynamics previously unattainable with single electrode recordings. The finite number of electrodes in planar MEAs (pMEAs), however, imposes a trade-off between the spatial resolution and the recording area. This limitation was circumvented in this paper through the custom design of experiment-specific ...