Rats with bilateral lesions of the lateral hypothalamus (LH) fail to exhibit sodium appetite. Lesions of the parabrachial nuclei (PBN) also block salt appetite. The PBN projection to the LH is largely ipsilateral. If these deficits are functionally dependent, damaging the PBN on one side and the LH on the other should also block Na appetite. First, bilateral ibotenic acid lesions of the LH were...

The role of mesencephalic reticular formation on testicular structure, seminal vesicles, adrenal glands and kidneys of albino rats was investigated. Mesencephalic reticular formation lesions were produced using two epoxy-coated stainless steel electrodes. Electrolytic lesions resulted in atrophy of the testes, seminal vesicles and adrenal glands. The degree of atrophy was statistically signific...

Increased release of pituitary prolactin as a result of placement of electrolytic lesions in the median eminence of the hypothalamus greatly accelerated the growth rate of carcinogen-induced mammary tumors in rats. Ovariectomy in these rats induced a rapid regression of tumors in spite of high plasma levels of prolactin. Grafting a pair of ovaries into ovariectomized rats with lesions of the me...

1. Systemic and regional haemodynamics were determined in conscious Wistar-Kyoto and spontaneously hypertensive rats with the radioactive microsphere technique after sham lesion or bilateral electrolytic lesion of the nuclei of the anterior hypothalamus. 2. Anterior hypothalamic lesions produced an increase in blood pressure, heart rate and cardiac output. 3. In the rats with lesions there were...

The effect of electrolytic lesions of varying size within the anterior part of the lateral hypothalamus (LH) on neocortical activity and quantitative sleep-waking relations was studied in male Wistar rats. It was found that extensive LH lesions caused simultaneously an abolishment of cortical desynchronizing reactions and an electroencephalographic insomnia. More restricted damage left the qual...

abstracf--trontal cortical dopamine (da) systems may play an inhibitory role inmotor behavior, possibly mediated through the nucleus accumbcns (nac). bilateral lesions ofda terminals in medial prefrontal cortex (mpfc) and bilateral electrolytic lesions in nac both induce hyperactivity in rats. however, unilateral nac lesions elicit hyperactivity only from the right hemisphere. the purpose of th...

Bilateral electrolytic lesions of the locus coeruleus were performed in rats. In comparison with controls, lesioned rats showed decreased acquisition of two-way avoidance response, less intertrial responses, longer latency of avoidance responses on the first day of training, and needed more trials to reach the extinction criterion. It is suggested that locus coeruleus, contrary to the ventral n...

Bilateral electrolytic lesions in the suprachiasmatic nuclei permanently eliminated nocturnal and circadian rhythms in drinking behavior and locomotor activity of albino rats. The generation of 24-hr behavioral rhythms and the entrainment of these rhythms to the light-dark cycle of environmental illumination may be coordinated by neurons in the suprachiasmatic region of the rat brain. Destructi...

The non-competitive NMDA receptor antagonist MK-801 elicits a behavioural syndrome in rodents characterized by hyperlocomotion and stereotypies, which is antagonized by antipsychotic drugs. NMDA receptor antagonists increase prefrontal cortex (PFC) activity in rodents, as assessed by electrophysiological and neurochemical measures. The increase in glutamate outflow induced by systemic MK-801 ad...