Rosai-Dorfman disease (RDD) is a rare non-Langerhans histiocytic disorder primarily involving lymph nodes. Extranodal RDD has heterogenous presentation, and isolated pulmonary involvement rare. We report the only case of presenting as an pleural mass. Our patient was 55-year-old female with multiple comorbidities who presented chest pain. Imaging revealed enlarging pleural-based lesion. She und...

Idiopathic myelofibrosis (MF) is a myeloproliferative syndrome characterized by an increase in bone marrow collagen. Megakaryocytes (Mks), which store growth factors in their alpha granules, are known to be involved in the pathogenesis of MF. Previously, mice given bone marrow grafts infected with a retrovirus carrying murine thrombopoietin (TPO) complementary DNA developed a disease resembling...

A 30-year-old woman presented with multiple swellings in the neck associated with febrile illness of 3 months' duration. She also complained of nasal blockade. The swellings were non-tender, non-matted with about 4-5 cm in size. CT scan of nose and paranasal sinuses revealed a mass in the right nasal cavity. Histopathology from cervical lymph nodes which showed large clusters of mononuclear foa...

A continuous line of lymphoblastic cells (AKR-A) was established in tissue culture from a spontaneous transplantable tumor of AKR mice. The cells have the following charac teristics: (a) rapid growth in suspension, (b) lack of adhesion to surfaces, (c) viral and cellular antigens of the Gross leukemia virus complex, (d) shedding of infectious Gross leukemia virus, and (e) tumorigenicity in AKR ...

Rosai-Dorfman disease (RDD) is a rare benign histiocytic proliferative disorder predominantly of the lymph nodes, which mostly occurs in children and young adults typically presenting with lymphadenopathy. Our case is of a 63 year-old African-American male who presented with subjective fever, weight loss, bilateral axillary and inguinal lymphadenopathy as well as auto-immune hemolytic anemia. T...