We aimed to investigate markers of oxidative stress and levels of endogenous and dietary antioxidants in 16 elite female soccer players in response to a 90-min game (average intensity 82+/-3% HRpeak). Blood samples were taken before, immediately and 21 h after the game. Plasma-oxidized glutathione, the ratio of reduced to oxidized glutathione (GSH:GSSG) and lipid peroxidation measured by d-ROMs...

Oxidative stress has been implicated as a contributing factor to neurodegeneration in Alzheimer's disease. An endogenous, low molecular weight (LMW) inhibitor from Alzheimer's brain inactivates the human brain muscarinic acetylcholine receptor (mAChR). The inhibitor prevents agonist and antagonist binding to the mAChR as assessed by radioligand binding studies. The LMW endogenous inhibitor, whi...

Dyslipidemia appears to be a conventional risk factor for acute myocardial infarction (AMI). Several studies have reported decreased levels of antioxidants and increased levels of ischemia-modified albumin (IscMA) and lipid peroxides in dyslipidemic myocardial infarct patients. However, literature search reveals no reports of normolipidemic AMI patients with reference to antioxidants and IscMA ...

Alzheimer’s disease (AD) brains are characterized by extensive oxidative stress. Additionally, large depositions of amyloid -peptide (A ) are observed, and many researchers opine that A is central to the pathogenesis of AD. Our laboratory combined these two observations in a comprehensive model for neurodegeneration in AD brains centered around A -induced oxidative stress. Given the oxidative s...

Oxidative stress occurs when the body’s enzymatic or non-enzymatic antioxidants are outweighed by endogenous exogenous free radicals. radicals, reactive oxygen species, and other biomolecule-damaging radicals can be generated during normal cellular metabolism react with proteins, lipids, DNA. In domains of biology medicine, have become increasingly important. They accumulate in a variety ways, ...

Cigarette/tobacco smoke/biomass fuel-induced oxidative and aldehyde/carbonyl stress are intimately associated with the progression and exacerbation of chronic obstructive pulmonary disease (COPD). Therefore, targeting systemic and local oxidative stress with antioxidants/redox modulating agents, or boosting the endogenous levels of antioxidants are likely to have beneficial effects in the treat...

1. Lipoic acid is an example of an existing drug whose therapeutic effect has been related to its antioxidant activity. 2. Antioxidant activity is a relative concept: it depends on the kind of oxidative stress and the kind of oxidizable substrate (e.g., DNA, lipid, protein). 3. In vitro, the final antioxidant activity of lipoic acid is determined by its concentration and by its antioxidant prop...

The development of cancer results from the interplay between genetic factors and the environment, and dietary factors have been identified as modulators of almost every step in the process. The complexity of this interplay between genetic factors and the nutritional environment is summarized in Fig. 1. In its initial stage, the development of a tumor requires genetic damage, caused either by en...

BACKGROUND Diabetic nephropathy (DN) is thought to be partially due to the injury of renal cells and the renal micro-environment by free radicals. Free radial scavenging agents that inhibit free radical damage may well prevent the development of underlying conditions such as mesangial expansion (by inhibiting extracellular matrix expression) in these patients. METHODS Using techniques for int...

Bacopa monniera (Bm), commonly known as brahmi, is widely used in the Indian System of Medicine as a notropic agent. The present study was designed to investigate the effects of oral administration of Bm (25, 75 and 150 mg/kg) for 21 days on: (i) myocardial antioxidant system and (ii) oxidative stress induced by isoproterenol (ISP) in the rat heart. Oral administration of Bm (75 and 150 mg/kg) ...