BACKGROUND Angiogenesis is essential for development, growth and advancement of solid tumors. During angiogenesis, ETS-1 is strongly expressed in vascular endothelial cells and the adjacent interstitial cells, while the inhibition of ETS-1 expression leads to suppression of angiogenesis. This prompted us to study the clinical implications of ETS-1 in relation to angiogenesis in uterine endometr...

BACKGROUND Endometrial cancers are the most common gynecologic cancers. Endometrial sampling is a preferred procedure for diagnosis of the endometrial pathology. It is performed routinely in many clinics prior to surgery in order to exclude an endometrial malignancy. We aimed to investigate the accuracy of endometrial sampling in the diagnosis of endometrial pathologies and which findings need ...

Previous studies of oncogene and tumor suppressor gene alterations have suggested that differences exist in the molecular pathogenesis of the various histological types of endometrial cancer. To elucidate further the molecular events involved in endometrial carcinogenesis, we examined global expression patterns of 16 nonendometrioid cancers (13 serous papillary and 3 clear cell), 19 endometrioi...

OBJECTIVE To determine the relative frequencies of gynaecological cancers in Ghana, age and parity distribution, stage of disease at presentation and the influence of age and parity on stage at presentation. DESIGN Retrospective observational study. SETTING Korle Bu Teaching Hospital, Accra, Ghana. SUBJECTS Cases of gynaecological cancers seen in a fifty two month period. RESULTS Cervic...

1. Alexa M, Hasenburg A, Battista MJ. The TCGA Molecular Classification of Endometrial Cancer and Its Possible Impact on Adjuvant Treatment Decisions. Cancers (Basel). 2021;13(6):1478. doi:10.3390/cancers13061478. CrossRef Google Scholar

The aim of the present study is to report the clinicopathologic features of endometrial cancers subsequently develepod after adjuvant treatment of breast cancer with tamoxifen. Seven endometrial cancers in tamoxifen-treated breast cancer patients were treated at our institution between 1994 and 2002. Medical reports of the patients were evaluated retrospectively. All patients were postmenopausa...

Peroxisome proliferator-activated receptors (PPAR) and retinoid X receptors (RXR) are implicated in the development of several obesity-related cancers. Little is known of either the expression or function of PPARs and RXRs in endometrial cancer although this increasingly common disease is highly associated with both obesity and insulin resistance. We investigated the expression of PPAR and RXR ...

background: vitamin d has a wide range of physiological functions in skeletal and nonskeletal tissues which may play a role in many diseases. the aim of this study was to evaluate the recent evidence regarding the effects of vitamin d on several health outcomes in women including breast cancer, ovarian and endometrial cancers, hypertension, and  osteoporosis. materials and methods: we searched ...

Defective DNA mismatch repair in human tumors leads to genome-wide instability of microsatellite repeats and a molecular phenotype referred to as microsatellite instability (MSI). MSI has been reported in a variety of cancers and is a consistent feature of tumors from patients with hereditary non-polyposis colorectal cancer. Approximately 20% of cancers of the uterine endometrium, the fifth mos...

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer susceptibility syndrome associated with inherited defects in the DNA mismatch repair system. HNPCC family members are at high risk for developing colorectal, endometrial, and ovarian cancers. Studies of HNPCC families have helped define the important role that mismatch repair genes play in the molecular pathogenes...