background: aub is a common cause of women’s referring to gynecologists. although hysteroscopy is known as the gold standard technique for diagnosing the cause of aub, sonohysterography is less invasive, and it is performed by general gynecologists. the purpose of this study was to evaluate the diagnostic performance of sonohysterography compared to the results of the endometrial biopsy, guided...

OBJECTIVES The aim of the study was to assess the concordance between the preoperative endometrial sampling and microscopic examination of the hysterectomy specimens in patients surgically treated for atypical endometrial hyperplasia and endometrial carcinoma. MATERIAL AND METHODS We analysed a group of 204 patients, of whom 160 (78.43%) underwent surgical treatment for cancer of the corpus u...

Objective: To determine the hysteroscopic appearance of endometrial hyperplasia in women with subsequently confirmed diagnosis of endometrial hyperplasia. Methodology: This study was done in Aria Hospital in Ahwaz,Iran fromJanuary 21, 2003 to May 24th 2005. Fifty women underwent hysteroscopy with eye direct biopsy of the endometrium. Cause of hysteroscopy was Abnormal Uterine Bleeding (AUB) in ...

Background and Objectives: Mutations of the P53 tumor suppressor gene and alterations in its protein expression often occur in a variety of human malignant tumors, including endometrial carcinoma, but the practical implications of this phenomenon are yet to be fully exploited. This study was designed to evaluate P53 protein expression in normal, hyperplastic and malignant endometrium by immunoh...

BACKGROUND Management of endometrial precancerous lesions has been of much debate due to inconsistencies in their classification, natural history and histologic diagnosis. Endometrial hyperplasia constitutes a wide range of histomorphologic features associated with high intra and interobserver diagnostic variability.Although traditional microscopic diagnosis is by far the most applicable method...

BACKGROUND A microRNA, miR-34a, plays a key role in inhibiting cellular transformation and carcinogenesis by controlling cell cycle regulation and cell proliferation in various human tumors. However, miR-34a has rarely been reported in endometrial cancer research in Korea. This study was undertaken to analyze miR-34a expression in simple endometrial hyperplasia and endometrial cancer, and to ev...

During aging, uncontrolled epithelial cell proliferation in the uterus results in endometrial hyperplasia and/or cancer development. The mTOR signaling pathway is one of the major regulators of aging as suppression of this pathway prolongs lifespan in model organisms. Genetic alterations in this pathway via mutations and/or amplifications are often encountered in endometrial cancers. However, t...

Background: Endometrial carcinoma is the most common malignancy in the female genital tract and associated with considerable degree of morbidity. Endometrial carcinoma has traditionally been divided into type I and type II cancers. Type I tumors are low grade endometrioid carcinoma that frequently arise in a setting of excess estrogen and associated with good clinical outcome while type II are ...

Hereditary nonpolyposis colorectal cancer (HNPCC)-related endometrial cancer is associated with mutations in DNA mismatch repair genes. However, chronological changes of these genes in the endometrium have not been studied in women from HNPCC families. Tissue samples of normal endometrium, endometrial hyperplasia without atypia and endometrial cancer were collected at different times from a 41-...

PURPOSE To evaluate the risk factors for endometrial hyperplasia concomitant endometrial polyps in pre- and post-menopausal women. MATERIALS AND METHODS A total of 203 patients undergoing endometrial sampling before hysterectomy were evaluated in this retrospective study. Data recorded were age, gravidity, parity, body mass index (BMI: weight(kg)/height(m)2), endometrial thickness (ET), menop...